| Literature DB >> 16043121 |
Hyun Sub Cheong1, Choon-Sik Park, Lyoung Hyo Kim, Byung Lae Park, Soo-Taek Uh, Yong Hooun Kim, Gune-Il Lym, Jong-Young Lee, Jong-Keuk Lee, Hung Tae Kim, Ha-Jung Ryu, Bok Ghee Han, Jun Woo Kim, Chan Park, Kuchan Kimm, Hyoung Doo Shin, Bermseok Oh.
Abstract
The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G > A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G > A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.Entities:
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Year: 2005 PMID： 16043121 DOI： 10.1016/j.bbrc.2005.07.019
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575