Mary P Fitzgerald1, Deborah Ayuste, Linda Brubaker. 1. Division of Female Pelvic Medicine and Reconstructive Surgery, Loyola University Medical Center, Maywood, IL 60153, USA. mfitzg8@lumc.edu
Abstract
OBJECTIVE: To quantify clinically important differences in common diary variables between asymptomatic controls and women with symptoms of overactive bladder (OAB), controlling for the effects of age and race. PATIENTS, SUBJECTS AND METHODS: The 24-h urinary diaries of 49 women with symptoms of OAB were compared to those of age- and race-matched asymptomatic controls. Control subjects did not have a physical examination. RESULTS: The 49 patients with OAB symptoms had a median (range) age of 51 (20-85) years, a body mass index of 25 (17-46) kg/m(2) and a parity of 2 (0-5). The median number of voids was significantly greater in women with OAB than asymptomatic controls (P < 0.001). The median value for mean voided volume was significantly lower in women with OAB than asymptomatic controls (P = 0.014). There was no difference in the maximum voided volume, total voided volume, daytime or night-time diuresis rates, voids per litre intake, or total fluid intake. CONCLUSIONS: This preliminary study suggests that a median reduction of three voids/24 h and an increase of 70 mL in the mean voided volume might be clinically important goals in therapeutic trials for treating OAB symptoms. This remains to be confirmed by further studies linking improvements in quality of life and the overall impression of bladder health with these quantitative diary variable changes.
OBJECTIVE: To quantify clinically important differences in common diary variables between asymptomatic controls and women with symptoms of overactive bladder (OAB), controlling for the effects of age and race. PATIENTS, SUBJECTS AND METHODS: The 24-h urinary diaries of 49 women with symptoms of OAB were compared to those of age- and race-matched asymptomatic controls. Control subjects did not have a physical examination. RESULTS: The 49 patients with OAB symptoms had a median (range) age of 51 (20-85) years, a body mass index of 25 (17-46) kg/m(2) and a parity of 2 (0-5). The median number of voids was significantly greater in women with OAB than asymptomatic controls (P < 0.001). The median value for mean voided volume was significantly lower in women with OAB than asymptomatic controls (P = 0.014). There was no difference in the maximum voided volume, total voided volume, daytime or night-time diuresis rates, voids per litre intake, or total fluid intake. CONCLUSIONS: This preliminary study suggests that a median reduction of three voids/24 h and an increase of 70 mL in the mean voided volume might be clinically important goals in therapeutic trials for treating OAB symptoms. This remains to be confirmed by further studies linking improvements in quality of life and the overall impression of bladder health with these quantitative diary variable changes.
Authors: Anne P Cameron; Jonathan B Wiseman; Abigail R Smith; Robert M Merion; Brenda W Gillespie; Catherine S Bradley; Cindy L Amundsen; Claire C Yang; Henry H Lai; John O L DeLancey; Margaret E Helmuth; Megan S Bradley; Nnena Agochukwu; Victor P Andreev; Ziya Kirkali; J Quentin Clemens Journal: Neurourol Urodyn Date: 2019-07-25 Impact factor: 2.696
Authors: Jose Carlos Truzzi; Cristiano Mendes Gomes; Carlos A Bezerra; Ivan Mauricio Plata; Jose Campos; Gustavo Luis Garrido; Fernando G Almeida; Marcio Augusto Averbeck; Alexandre Fornari; Anibal Salazar; Arturo Dell'Oro; Caio Cintra; Carlos Alberto Ricetto Sacomani; Juan Pablo Tapia; Eduardo Brambila; Emilio Miguel Longo; Flavio Trigo Rocha; Francisco Coutinho; Gabriel Favre; Jose Antonio Garcia; Juan Castano; Miguel Reyes; Rodrigo Eugenio Leyton; Ruiter Silva Ferreira; Sergio Duran; Vanda Lopez; Ricardo Reges Journal: Int Braz J Urol Date: 2016 Mar-Apr Impact factor: 1.541