| Literature DB >> 16041651 |
Yao-Haur Kuo1, Ming-Der Wu, Ray-Ling Huang, Li-Ming Yang Kuo, Ya-Wen Hsu, Chia-Ching Liaw, Chia-Cheng Hung, Ya-Ching Shen, Chi-Wi Ong.
Abstract
Bioassay-directed fractionation of the EtOAc extract of Kadsura japonica has led to the isolation of six new C18 dibenzocyclooctadiene lignans, schizanrins I, J, K, L, M, N, along with four known C19 homolignans, taiwanschirins A, B, C, and heteroclitin F. The elucidations of the new structures were based on spectral analysis. Bioassay evaluation against human type B hepatitis revealed that taiwanschirins A and B showed strong activity for anti-HBsAg and a medium effect for anti-HBeAg at 25 microg/mL (12.9 and 11.9 microM for taiwanschirins A and B, respectively).Entities:
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Year: 2005 PMID： 16041651 DOI： 10.1055/s-2005-871271
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352