Literature DB >> 16041050

Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.

Catherine J Clark1, Gillian M Mackay, George A Smythe, Sonia Bustamante, Trevor W Stone, R Stephen Phillips.   

Abstract

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.

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Year:  2005        PMID： 16041050      PMCID： PMC1201246          DOI： 10.1128/IAI.73.8.5249-5251.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Cytokine and chemokine mRNA expression in neutrophils from CBA/NSlc mice infected with Plasmodium berghei ANKA that induces experimental cerebral malaria.

Authors:  L Chen; F Sendo
Journal:  Parasitol Int       Date:  2001-07       Impact factor: 2.230

Review 2.  Kynurenines in the CNS: from endogenous obscurity to therapeutic importance.

Authors:  T W Stone
Journal:  Prog Neurobiol       Date:  2001-06       Impact factor: 11.685

3.  Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry.

Authors:  G A Smythe; O Braga; B J Brew; R S Grant; G J Guillemin; S J Kerr; D W Walker
Journal:  Anal Biochem       Date:  2002-02-01       Impact factor: 3.365

4.  The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria.

Authors:  Isabelle M Medana; Tran Tinh Hien; Nicholas P Day; Nguyen Hoan Phu; Nguyen Thi Hoang Mai; Ly Van Chu'ong; Tran Thi Hong Chau; Anne Taylor; Houta Salahifar; Roland Stocker; George Smythe; Gareth D H Turner; Jeremy Farrar; Nicholas J White; Nicholas H Hunt
Journal:  J Infect Dis       Date:  2002-02-14       Impact factor: 5.226

5.  Differences in the neurochemical characteristics of the cortex and striatum of mice with cerebral malaria.

Authors:  C J Clark; R S Phillips; R B McMillan; I O Montgomery; T W Stone
Journal:  Parasitology       Date:  2005-01       Impact factor: 3.234

Review 6.  Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria.

Authors:  Nicholas H Hunt; Georges E Grau
Journal:  Trends Immunol       Date:  2003-09       Impact factor: 16.687

7.  Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.

Authors:  Isabelle M Medana; Nicholas P J Day; Houta Salahifar-Sabet; Roland Stocker; George Smythe; Lloyd Bwanaisa; Alfred Njobvu; Kondwani Kayira; Gareth D H Turner; Terrie E Taylor; Nicholas H Hunt
Journal:  J Infect Dis       Date:  2003-09-09       Impact factor: 5.226

Review 8.  Tryptophan metabolites and brain disorders.

Authors:  Trevor W Stone; Gillian M Mackay; Caroline M Forrest; Catherine J Clark; L Gail Darlington
Journal:  Clin Chem Lab Med       Date:  2003-07       Impact factor: 3.694

9.  MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS.

Authors:  Isaias Glezer; Carolina Demarchi Munhoz; Elisa Mitiko Kawamoto; Tania Marcourakis; Maria Christina Werneck Avellar; Cristoforo Scavone
Journal:  Neuropharmacology       Date:  2003-12       Impact factor: 5.250

10.  The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages.

Authors:  M C Bosco; A Rapisarda; S Massazza; G Melillo; H Young; L Varesio
Journal:  J Immunol       Date:  2000-03-15       Impact factor: 5.422
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  47 in total

1.  Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice.

Authors:  Paul B Larkin; Korrapati V Sathyasaikumar; Francesca M Notarangelo; Hiroshi Funakoshi; Toshikazu Nakamura; Robert Schwarcz; Paul J Muchowski
Journal:  Biochim Biophys Acta       Date:  2016-07-05

2.  Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain.

Authors:  Geoffroy Laumet; Wenjun Zhou; Robert Dantzer; Jules D Edralin; XiaoJiao Huo; David P Budac; Jason C O'Connor; Anna W Lee; Cobi J Heijnen; Annemieke Kavelaars
Journal:  Brain Behav Immun       Date:  2017-07-11       Impact factor: 7.217

3.  Kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Authors:  Abdulla A-B Badawy
Journal:  Psychopharmacology (Berl)       Date:  2016-11-24       Impact factor: 4.530

Review 4.  The kynurenine pathway and the brain: Challenges, controversies and promises.

Authors:  Robert Schwarcz; Trevor W Stone
Journal:  Neuropharmacology       Date:  2016-08-07       Impact factor: 5.250

5.  In vitro antimalarial activity and drug interactions of fenofibric acid.

Authors:  Rina P M Wong; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2012-03-19       Impact factor: 5.191

Review 6.  NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns.

Authors:  Hassina Massudi; Ross Grant; Gilles J Guillemin; Nady Braidy
Journal:  Redox Rep       Date:  2012       Impact factor: 4.412

7.  Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

Authors:  Daniel Zwilling; Shao-Yi Huang; Korrapati V Sathyasaikumar; Francesca M Notarangelo; Paolo Guidetti; Hui-Qiu Wu; Jason Lee; Jennifer Truong; Yaisa Andrews-Zwilling; Eric W Hsieh; Jamie Y Louie; Tiffany Wu; Kimberly Scearce-Levie; Christina Patrick; Anthony Adame; Flaviano Giorgini; Saliha Moussaoui; Grit Laue; Arash Rassoulpour; Gunnar Flik; Yadong Huang; Joseph M Muchowski; Eliezer Masliah; Robert Schwarcz; Paul J Muchowski
Journal:  Cell       Date:  2011-06-10       Impact factor: 41.582

8.  Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression.

Authors:  Angika Basant; Mayuri Rege; Shobhona Sharma; Haripalsingh M Sonawat
Journal:  Malar J       Date:  2010-04-23       Impact factor: 2.979

9.  5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones.

Authors:  Andrew J Smith; Robert A Smith; Trevor W Stone
Journal:  Neurotox Res       Date:  2009-03-04       Impact factor: 3.911

Review 10.  Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.

Authors:  Robert Schwarcz; Paolo Guidetti; Korrapati V Sathyasaikumar; Paul J Muchowski
Journal:  Prog Neurobiol       Date:  2009-04-24       Impact factor: 11.685
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