Literature DB >> 16041048

Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides.

Barbara E Menzies1, Aimee Kenoyer.   

Abstract

Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.

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Year:  2005        PMID： 16041048      PMCID： PMC1201242          DOI： 10.1128/IAI.73.8.5241-5244.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  15 in total

Review 1.  Defensins: antimicrobial peptides of innate immunity.

Authors:  Tomas Ganz
Journal:  Nat Rev Immunol       Date:  2003-09       Impact factor: 53.106

2.  Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.

Authors:  L Liu; L Wang; H P Jia; C Zhao; H H Heng; B C Schutte; P B McCray; T Ganz
Journal:  Gene       Date:  1998-11-19       Impact factor: 3.688

3.  Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells.

Authors:  G Diamond; V Kaiser; J Rhodes; J P Russell; C L Bevins
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

4.  Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.

Authors:  Nicolas W J Schröder; Siegfried Morath; Christian Alexander; Lutz Hamann; Thomas Hartung; Ulrich Zähringer; Ulf B Göbel; Joerg R Weber; Ralf R Schumann
Journal:  J Biol Chem       Date:  2003-02-19       Impact factor: 5.157

5.  Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent.

Authors:  Martin Mempel; Verena Voelcker; Gabriele Köllisch; Christian Plank; Roland Rad; Markus Gerhard; Christina Schnopp; Peter Fraunberger; Autar K Walli; Johannes Ring; Dietrich Abeck; Markus Ollert
Journal:  J Invest Dermatol       Date:  2003-12       Impact factor: 8.551

6.  Intracellular calcium in signaling human beta-defensin-2 expression in oral epithelial cells.

Authors:  S Krisanaprakornkit; D Jotikasthira; B A Dale
Journal:  J Dent Res       Date:  2003-11       Impact factor: 6.116

7.  Invasion of human keratinocytes by Staphylococcus aureus and intracellular bacterial persistence represent haemolysin-independent virulence mechanisms that are followed by features of necrotic and apoptotic keratinocyte cell death.

Authors:  M Mempel; C Schnopp; M Hojka; H Fesq; S Weidinger; M Schaller; H C Korting; J Ring; D Abeck
Journal:  Br J Dermatol       Date:  2002-06       Impact factor: 9.302

8.  Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes.

Authors:  Kazushige Midorikawa; Kazuhisa Ouhara; Hitoshi Komatsuzawa; Toshihisa Kawai; Sakuo Yamada; Tamaki Fujiwara; Kenshi Yamazaki; Koji Sayama; Martin A Taubman; Hidemi Kurihara; Koji Hashimoto; Motoyuki Sugai
Journal:  Infect Immun       Date:  2003-07       Impact factor: 3.441

9.  Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid.

Authors:  Jürgen Harder; Ulf Meyer-Hoffert; Kai Wehkamp; Lars Schwichtenberg; Jens-Michael Schröder
Journal:  J Invest Dermatol       Date:  2004-09       Impact factor: 8.551

10.  Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

Authors:  S H Yuspa; A E Kilkenny; P M Steinert; D R Roop
Journal:  J Cell Biol       Date:  1989-09       Impact factor: 10.539
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  16 in total

1.  Skin tissue engineering for the infected wound site: biodegradable PLA nanofibers and a novel approach for silver ion release evaluated in a 3D coculture system of keratinocytes and Staphylococcus aureus.

Authors:  Mahsa Mohiti-Asli; Behnam Pourdeyhimi; Elizabeth G Loboa
Journal:  Tissue Eng Part C Methods       Date:  2014-03-21       Impact factor: 3.056

2.  Innate immunity and the role of the antimicrobial peptide cathelicidin in inflammatory skin disease.

Authors:  Keith D Roby; Anna Di Nardo
Journal:  Drug Discov Today Dis Mech       Date:  2013-12-01

3.  Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes.

Authors:  Barbara E Menzies; Aimee Kenoyer
Journal:  Infect Immun       Date:  2006-09-05       Impact factor: 3.441

4.  Severity of Staphylococcus aureus infection of the skin is associated with inducibility of human beta-defensin 3 but not human beta-defensin 2.

Authors:  Philipp Zanger; Johannes Holzer; Regina Schleucher; Helmut Scherbaum; Birgit Schittek; Sabine Gabrysch
Journal:  Infect Immun       Date:  2010-04-19       Impact factor: 3.441

5.  Systemic dissemination and cutaneous damage in a mouse model of staphylococcal skin infections.

Authors:  Beth L Hahn; Charles C Onunkwo; Christopher J Watts; Peter G Sohnle
Journal:  Microb Pathog       Date:  2009-05-03       Impact factor: 3.738

6.  Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus.

Authors:  Scott N Dean; Barney M Bishop; Monique L van Hoek
Journal:  BMC Microbiol       Date:  2011-05-23       Impact factor: 3.605

7.  Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways.

Authors:  Debajyoti Ghosh; Lili Ding; Umasundari Sivaprasad; Esmond Geh; Jocelyn Biagini Myers; Jonathan A Bernstein; Gurjit K Khurana Hershey; Tesfaye B Mersha
Journal:  PLoS One       Date:  2015-12-30       Impact factor: 3.240

8.  Ultrastructural immunolocalization of beta-defensin-27 in granulocytes of the dermis and wound epidermis of lizard suggests they contribute to the anti-microbial skin barrier.

Authors:  Lorenzo Alibardi
Journal:  Anat Cell Biol       Date:  2013-12-24

Review 9.  Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design.

Authors:  Aisling F Brown; John M Leech; Thomas R Rogers; Rachel M McLoughlin
Journal:  Front Immunol       Date:  2014-01-08       Impact factor: 7.561

10.  Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and speG-mediated adaptations for survival on skin.

Authors:  Paul J Planet; Samuel J LaRussa; Ali Dana; Hannah Smith; Amy Xu; Chanelle Ryan; Anne-Catrin Uhlemann; Sam Boundy; Julia Goldberg; Apurva Narechania; Ritwij Kulkarni; Adam J Ratner; Joan A Geoghegan; Sergios-Orestis Kolokotronis; Alice Prince
Journal:  mBio       Date:  2013-12-17       Impact factor: 7.867
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