Literature DB >> 16041046

Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18.

T Dileepan1, M S Kannan, B Walcheck, P Thumbikat, S K Maheswaran.   

Abstract

To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine x human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18.

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Year:  2005        PMID： 16041046      PMCID： PMC1201247          DOI： 10.1128/IAI.73.8.5233-5237.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


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