Literature DB >> 16041040

Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

Elaine Bignell1, Susana Negrete-Urtasun, Ana Maria Calcagno, Herbert N Arst, Tom Rogers, Ken Haynes.   

Abstract

While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47(phox)(-/-) mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47(phox)(-/-) murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47(phox)(-/-) mice.

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Year:  2005        PMID： 16041040      PMCID： PMC1201179          DOI： 10.1128/IAI.73.8.5204-5207.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  22 in total

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Authors:  J P Latgé
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4.  The Aspergillus pH-responsive transcription factor PacC regulates virulence.

Authors:  Elaine Bignell; Susana Negrete-Urtasun; Ana Maria Calcagno; Ken Haynes; Herbert N Arst; Tom Rogers
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5.  Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.

Authors:  M A De Groote; U A Ochsner; M U Shiloh; C Nathan; J M McCord; M C Dinauer; S J Libby; A Vazquez-Torres; Y Xu; F C Fang
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

6.  Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.

Authors:  A Vazquez-Torres; Y Xu; J Jones-Carson; D W Holden; S M Lucia; M C Dinauer; P Mastroeni; F C Fang
Journal:  Science       Date:  2000-03-03       Impact factor: 47.728

7.  Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus.

Authors:  D E Morgenstern; M A Gifford; L L Li; C M Doerschuk; M C Dinauer
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Authors:  J D Pollock; D A Williams; M A Gifford; L L Li; X Du; J Fisherman; S H Orkin; C M Doerschuk; M C Dinauer
Journal:  Nat Genet       Date:  1995-02       Impact factor: 38.330

Review 9.  The NADPH oxidase and chronic granulomatous disease.

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Journal:  Mol Med Today       Date:  1996-03

10.  The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH.

Authors:  J Tilburn; S Sarkar; D A Widdick; E A Espeso; M Orejas; J Mungroo; M A Peñalva; H N Arst
Journal:  EMBO J       Date:  1995-02-15       Impact factor: 11.598
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  8 in total

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2.  Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.

Authors:  Carly G Dennis; William R Greco; Yseult Brun; Richard Youn; Harry K Slocum; Ralph J Bernacki; Russell Lewis; Nathan Wiederhold; Steven M Holland; Ruta Petraitiene; Thomas J Walsh; Brahm H Segal
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

3.  Evidence for novel pH-dependent regulation of Candida albicans Rim101, a direct transcriptional repressor of the cell wall beta-glycosidase Phr2.

Authors:  Yong-Un Baek; Samuel J Martin; Dana A Davis
Journal:  Eukaryot Cell       Date:  2006-09

4.  Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish.

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5.  Role of NADPH oxidase in host defense against aspergillosis.

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6.  Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions.

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Journal:  Cell Microbiol       Date:  2008-07-04       Impact factor: 3.715

Review 7.  Regulation of innate immunity by NADPH oxidase.

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Journal:  Free Radic Biol Med       Date:  2012-05-01       Impact factor: 7.376

8.  Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense.

Authors:  R Robert Vethanayagam; Nikolaos G Almyroudis; Melissa J Grimm; David C Lewandowski; Christine T N Pham; Timothy S Blackwell; Ruta Petraitiene; Vidmantas Petraitis; Thomas J Walsh; Constantin F Urban; Brahm H Segal
Journal:  PLoS One       Date:  2011-12-07       Impact factor: 3.240
  8 in total

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