Literature DB >> 16040160

Facile synthesis of active antitubercular, cytotoxic and antibacterial agents: a Michael addition approach.

Madhukar S Chande1, Ranjit S Verma, Pravin A Barve, Rahul R Khanwelkar, R B Vaidya, K B Ajaikumar.   

Abstract

Spiro derivatives of oxindole and isoxazole-5-one were synthesized by using Michael addition reaction, highlighting the regioselective approach towards the synthesis of Michael diadduct followed by condensation of Michael diadduct. The spiro compound 4 showed antitubercular activity against Mycobacterium tuberculosis H37Rv whereas spiro compound 9 possesses pronounced anticancer and antibacterial profile.

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Year:  2005        PMID： 16040160     DOI： 10.1016/j.ejmech.2005.06.004

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  21 in total

Review 1.  Recent synthetic strategies toward the synthesis of spirocyclic compounds comprising six-membered carbocyclic/heterocyclic ring systems.

Authors:  Kashaf Babar; Ameer Fawad Zahoor; Sajjad Ahmad; Rabia Akhtar
Journal:  Mol Divers       Date:  2020-07-21       Impact factor: 2.943

2.  Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple.

Authors:  Alexander S Filatov; Olesya V Khoroshilova; Anna G Larina; Vitali M Boitsov; Alexander V Stepakov
Journal:  Beilstein J Org Chem       Date:  2022-06-29       Impact factor: 2.544

3.  5''-(4-Chloro-benzyl-idene)-1',1''-dimethyl-3'-phenyl-acenaphthene-1-spiro-2'-pyrrolidine-3'-spiro-3''-pyridine-2,4''-dione.

Authors:  S Pandiarajan; S N Saravanamoorthy; B Ravi Kumar; R Ranjith Kumar; S Athimoolam
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

4.  Ethyl 1'-[1-(4-methoxyphenyl)-3-phenoxy-4-phenylazetidin-1-yl]-1,3-dioxo-2',3',5',6',7',7a'-hexahydroindan-2-spiro-3'-1'H-pyrrolizine-2'-carboxylate.

Authors:  E Theboral Sugi Kamala; S Nirmala; L Sudha; N Arumugam; R Raghunathan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-30

5.  4-(4-Methoxy-phen-yl)-3-methyl-1,6-di-oxa-2,8-diaza-s-indacen-5(7H)-one.

Authors:  Li-Xin Zhang; Xiao-Hong Zhang; Shu Yan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-18

6.  1'-Methyl-4'-(1-naphth-yl)-3''-(1-naphthyl-methyl-ene)acenaphthene-1-spiro-2'-pyrrolidine-3'-spiro-1''-cyclo-hexane-2,2''-dione.

Authors:  S Athimoolam; V Anu Radha; S Asath Bahadur; R Ranjith Kumar; S Perumal
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

7.  4'-[5-(4-Fluoro-phen-yl)pyridin-3-yl]-1'-methyl-dispiro-[indan-2,2'-pyrrolidine-3',2''-indan]-1,3,1''-trione.

Authors:  Ang Chee Wei; Mohamed Ashraf Ali; Rusli Ismail; Ching Kheng Quah; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-27

8.  1'-Methyl-4'-phenyldispiro-[indan-2,2'-pyrrolidine-3',2''-indan]-1,3,1''-trione.

Authors:  Ang Chee Wei; Mohamed Ashraf Ali; Tan Soo Choon; Ching Kheng Quah; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-27

9.  5''-(2,4-Dichloro-benzyl-idene)-1'-(2,4-dichloro-phen-yl)-1''-methyl-1',2',3',5',6',7',8',8a'-octa-hydro-dispiro-[acenaphthyl-ene-1,3'-indolizine-2',3''-piperidine]-2,4''(1H)-dione.

Authors:  J Suresh; R Vishnupriya; R Ranjith Kumar; S Sivakumar; P L Nilantha Lakshman
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-08

10.  3''-(2-Fluoro-benzyl-idene)-4'-(2-fluoro-phen-yl)-1'-methyl-dispiro-[acenaphthyl-ene-1,2'-pyrrolidine-3',1''-cyclo-penta-ne]-2,2''-dione.

Authors:  Gao-Zhi Chen; Xiao-Yan Wei; Yi Wang; Lu-Qing Ren; Xiao-Kun Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-01-19
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