| Literature DB >> 16039715 |
Yang Yang1, Seisho Takeuchi, Wolf K Hofmann, Takayuki Ikezoe, Jacques J M van Dongen, Tomasz Szczepański, Claus R Bartram, Norihide Yoshino, Hirokuni Taguchi, H Phillip Koeffler.
Abstract
Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARbeta, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARbeta was more frequent in adult ALL than that in childhood ALL (p=0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL (p=0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL (p=0.01).Entities:
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Year: 2005 PMID： 16039715 DOI： 10.1016/j.leukres.2005.06.002
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156