Literature DB >> 16039518

Designing effective hybrid toxins.

John A Katzenellenbogen1.   

Abstract

A study of a well-designed androgen-mustard conjugate provides evidence supporting a novel mechanism for its selective toxicity in androgen-receptor-positive cancer cells. This represents a solid step forward on the path toward effective hybrid toxins for targeted cancer therapy.

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Year:  2005        PMID: 16039518     DOI: 10.1016/j.chembiol.2005.07.002

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  1 in total

1.  Synthesis and preliminary evaluation steroidal antiestrogen-geldanamycin conjugates.

Authors:  J Adam Hendricks; Robert N Hanson; Michael Amolins; John M Mihelcic; Brian S Blagg
Journal:  Bioorg Med Chem Lett       Date:  2013-04-04       Impact factor: 2.823

  1 in total

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