Literature DB >> 16039157

Linking signalling pathways, thymic stroma integrity and autoimmunity.

Jens Derbinski1, Bruno Kyewski.   

Abstract

Medullary thymic epithelial cells (mTECs) are indispensable for self-tolerance to peripheral organs by virtue of their expression of a host of tissue-restricted self-antigens. The full extent of this promiscuous gene expression is confined to functionally mature mTECs. Consequently, any interference with signalling pathways directing the differentiation and/or proliferation of this mature subset will affect the scope of central tolerance and potentially predispose to autoimmunity. In a recent study, tumour necrosis factor receptor-associated factor 6 (TRAF6) has been identified as an essential component of a new signalling pathway directing mTEC development.

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Year:  2005        PMID： 16039157     DOI： 10.1016/j.it.2005.07.006

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  16 in total

1.  NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells.

Authors:  Baochun Zhang; Zhe Wang; Jane Ding; Pärt Peterson; William T Gunning; Han-Fei Ding
Journal:  J Biol Chem       Date:  2006-10-17       Impact factor: 5.157

2.  The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells.

Authors:  Natalie Seach; Tomoo Ueno; Anne L Fletcher; Tamara Lowen; Monika Mattesich; Christian R Engwerda; Hamish S Scott; Carl F Ware; Ann P Chidgey; Daniel H D Gray; Richard L Boyd
Journal:  J Immunol       Date:  2008-04-15       Impact factor: 5.422

Review 3.  Control of central and peripheral tolerance by Aire.

Authors:  Todd C Metzger; Mark S Anderson
Journal:  Immunol Rev       Date:  2011-05       Impact factor: 12.988

Review 4.  Clues to immune tolerance: the monogenic autoimmune syndromes.

Authors:  Michael Waterfield; Mark S Anderson
Journal:  Ann N Y Acad Sci       Date:  2010-10-22       Impact factor: 5.691

Review 5.  The role of the thymus in tolerance.

Authors:  Adam D Griesemer; Eric C Sorenson; Mark A Hardy
Journal:  Transplantation       Date:  2010-09-15       Impact factor: 4.939

6.  Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.

Authors:  Nichole M Danzl; Laura T Donlin; Konstantina Alexandropoulos
Journal:  J Exp Med       Date:  2010-04-19       Impact factor: 14.307

7.  Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

Authors:  Izumi Ohigashi; Saulius Zuklys; Mie Sakata; Carlos E Mayer; Saule Zhanybekova; Shigeo Murata; Keiji Tanaka; Georg A Holländer; Yousuke Takahama
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-29       Impact factor: 11.205

8.  NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis.

Authors:  L Boutaffala; M J M Bertrand; C Remouchamps; G Seleznik; F Reisinger; M Janas; C Bénézech; M T Fernandes; S Marchetti; F Mair; C Ganeff; A Hupalowska; J-E Ricci; B Becher; J Piette; P Knolle; J Caamano; P Vandenabeele; M Heikenwalder; E Dejardin
Journal:  Cell Death Differ       Date:  2015-06-05       Impact factor: 15.828

9.  Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency.

Authors:  Francesca Rucci; Pietro Luigi Poliani; Stefano Caraffi; Tiziana Paganini; Elena Fontana; Silvia Giliani; Frederick W Alt; Luigi Daniele Notarangelo
Journal:  Front Immunol       Date:  2011-05-10       Impact factor: 7.561

Review 10.  Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance.

Authors:  Roberto Perniola
Journal:  Clin Dev Immunol       Date:  2012-10-22
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