| Literature DB >> 16039124 |
Meizi He1, Dekai Yuan, Wei Lin, Ruifang Pang, Xiaolin Yu, Ming Yang.
Abstract
Four new isoquinoline derivatives bearing guanidinium group or amino group-terminated side chain were synthesized to target the HIV-1 TAR element. Their abilities to bind TAR RNA and inhibit Tat-TAR RNA interaction were determined by CE analysis, a Tat-dependent HIV-1 LTR-driven CAT assay and SIV-induced syncytium evaluation.Entities:
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Year: 2005 PMID： 16039124 DOI： 10.1016/j.bmcl.2005.01.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823