Literature DB >> 16038566

Morphinane alkaloids with cell protective effects from Sinomenium acutum.

Guan-Hu Bao1, Guo-Wei Qin, Rui Wang, Xi-Can Tang.   

Abstract

One new morphinane alkaloid, sinomenine N-oxide (1), and one new natural occurring morphinane alkaloid, N-demethylsinomenine (2), together with six known alkaloids, 7,8-didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (3), sinomenine (4), sinoacutine (5), N-norsinoacutine, acutumine, and acutumidine, were isolated from the stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 2, 3, and 5 have protective effects against hydrogen peroxide-induced cell injury.

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Year:  2005        PMID： 16038566     DOI： 10.1021/np050112+

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice.

Authors:  June Bryan I de la Peña; Hye Lim Lee; Seo Young Yoon; Gun Hee Kim; Yong Soo Lee; Jae Hoon Cheong
Journal:  J Nat Med       Date:  2013-03-03       Impact factor: 2.343

2.  Sinomenine Protects PC12 Neuronal Cells against H2O2-induced Cytotoxicity and Oxidative Stress via a ROS-dependent Up-regulation of Endogenous Antioxidant System.

Authors:  Hua Fan; Qing Shu; Xinlei Guan; Jiegang Zhao; Junqiang Yan; Xiangming Li; Jiangbo Liu; Zhaohui Jia; Jian Shi; Juan Li
Journal:  Cell Mol Neurobiol       Date:  2017-02-03       Impact factor: 5.046

3.  Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels.

Authors:  Wen-Ning Wu; Peng-Fei Wu; Xiang-Long Chen; Zui Zhang; Jun Gu; Yuan-Jian Yang; Qiu-Ju Xiong; Lan Ni; Fang Wang; Jian-Guo Chen
Journal:  Br J Pharmacol       Date:  2011-11       Impact factor: 8.739

4.  Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis.

Authors:  Dan Sun; Mengge Zhou; Xuhui Ying; Binfeng Cheng; Yanqi Han; Yan Nie; Yuanyuan Hou; Gang Bai
Journal:  BMC Complement Altern Med       Date:  2014-09-25       Impact factor: 3.659

5.  Sinomenine, an Alkaloid Derived from Sinomenium acutum Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep in Rodents.

Authors:  Jae Hyeon Yoo; Tae-Woo Ha; Jin Tae Hong; Ki-Wan Oh
Journal:  Biomol Ther (Seoul)       Date:  2017-11-01       Impact factor: 4.634

6.  N-Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and inflammatory pain in mice.

Authors:  Zhiyong Zhou; Nanqing Qiu; Yuntao Ou; Qianqian Wei; Wenting Tang; Mingcong Zheng; Yaluan Xing; Jie-Jia Li; Yong Ling; Junxu Li; Qing Zhu
Journal:  Sci Rep       Date:  2021-04-29       Impact factor: 4.379
  6 in total

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