Literature DB >> 16038556

A labdane diterpene glucoside from the rhizomes of Curcuma mangga.

Faridah Abas1, Nordin H Lajis, Khozirah Shaari, Daud Ahmad Israf, Johnson Stanslas, Umi Kalsom Yusuf, Salahuddin Mohd Raof.   

Abstract

A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, HSQC, HMBC) NMR techniques. All diarylheptanoids and scopoletin showed significant antioxidant activity. Zerumin B, demethoxycurcumin, bisdemethoxycurcumin, and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.

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Year:  2005        PMID： 16038556     DOI： 10.1021/np0500171

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

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