Literature DB >> 16038553

Latifolians A and B, novel JNK3 kinase inhibitors from the Papua New Guinean plant Gnetum latifolium.

Simone J Rochfort1, Leanne Towerzey, Anthony Carroll, Gordon King, Adam Michael, Greg Pierens, Topul Rali, Joanne Redburn, Jaqueline Whitmore, Ronald J Quinn.   

Abstract

As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR analysis. The relative configurations were assigned after examination of the ROESY data and through detailed molecular modeling studies.

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Year:  2005        PMID: 16038553     DOI: 10.1021/np049616i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  7 in total

1.  Natural product-derived quaternary ammonium compounds with potent antimicrobial activity.

Authors:  Maureen D Joyce; Megan C Jennings; Celina N Santiago; Madison H Fletcher; William M Wuest; Kevin Pc Minbiole
Journal:  J Antibiot (Tokyo)       Date:  2015-11-18       Impact factor: 2.649

Review 2.  Is it time for artificial intelligence to predict the function of natural products based on 2D-structure.

Authors:  Miaomiao Liu; Peter Karuso; Yunjiang Feng; Esther Kellenberger; Fei Liu; Can Wang; Ronald J Quinn
Journal:  Medchemcomm       Date:  2019-06-06       Impact factor: 3.597

Review 3.  Application of the Asymmetric Pictet-Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds.

Authors:  Majid M Heravi; Vahideh Zadsirjan; Masumeh Malmir
Journal:  Molecules       Date:  2018-04-18       Impact factor: 4.411

Review 4.  Inhibitors of c-Jun N-terminal kinases: JuNK no more?

Authors:  Marie A Bogoyevitch; Peter G Arthur
Journal:  Biochim Biophys Acta       Date:  2007-10-11

5.  Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines.

Authors:  Alexia N Kim; Aurapat Ngamnithiporn; Michael D Bartberger; Brian M Stoltz
Journal:  Chem Sci       Date:  2022-02-18       Impact factor: 9.825

Review 6.  c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease.

Authors:  Ramon Yarza; Silvia Vela; Maite Solas; Maria J Ramirez
Journal:  Front Pharmacol       Date:  2016-01-12       Impact factor: 5.810

Review 7.  Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment.

Authors:  Oriol Busquets; Miren Ettcheto; Amanda Cano; Patricia R Manzine; Elena Sánchez-Lopez; Triana Espinosa-Jiménez; Ester Verdaguer; Rubén Dario Castro-Torres; Carlos Beas-Zarate; Francesc X Sureda; Jordi Olloquequi; Carme Auladell; Jaume Folch; Antoni Camins
Journal:  Int J Mol Sci       Date:  2019-12-30       Impact factor: 5.923

  7 in total

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