Literature DB >> 16038533

The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists.

Fang-Rong Chang1, Ken-ichiro Hayashi, Nam-Hai Chua, Shuichi Kamio, Zih-You Huang, Hiroshi Nozaki, Yang-Chang Wu.   

Abstract

The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max and Pueraria lobata) and pure compounds (e.g., 17beta-estradiol (1), genistein (10), and daidzein (11)) and also to distinguish effects of structural changes on activity. Thus, this rapid sensitive system was proven to be suitable for the discovery of natural products with estrogenic activity.

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Year:  2005        PMID： 16038533     DOI： 10.1021/np050121i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

1.  Bioassay of estrogenic compounds in transgenic Arabidopsis plants carrying a recombinant human estrogen receptor gene and a GFP reporter gene.

Authors:  Hideyuki Inui; Hideaki Sasaki; Nam-Hai Chua; Hideo Ohkawa
Journal:  Transgenic Res       Date:  2009-05-29       Impact factor: 2.788

2.  Expression of flavonoid 6-hydroxylase candidate genes in normal and mutant soybean genotypes for glycitein content.

Authors:  Marie-Pierre Artigot; Mathieu Baes; Jean Daydé; Monique Berger
Journal:  Mol Biol Rep       Date:  2013-05-22       Impact factor: 2.316

3.  Developing a molecular roadmap of drug-food interactions.

Authors:  Kasper Jensen; Yueqiong Ni; Gianni Panagiotou; Irene Kouskoumvekaki
Journal:  PLoS Comput Biol       Date:  2015-02-10       Impact factor: 4.475

4.  Development and use of a switchgrass (Panicum virgatum L.) transformation pipeline by the BioEnergy Science Center to evaluate plants for reduced cell wall recalcitrance.

Authors:  Richard S Nelson; C Neal Stewart; Jiqing Gou; Susan Holladay; Lina Gallego-Giraldo; Amy Flanagan; David G J Mann; Hiroshi Hisano; Wegi A Wuddineh; Charleson R Poovaiah; Avinash Srivastava; Ajaya K Biswal; Hui Shen; Luis L Escamilla-Treviño; Jiading Yang; C Frank Hardin; Rangaraj Nandakumar; Chunxiang Fu; Jiyi Zhang; Xirong Xiao; Ryan Percifield; Fang Chen; Jeffrey L Bennetzen; Michael Udvardi; Mitra Mazarei; Richard A Dixon; Zeng-Yu Wang; Yuhong Tang; Debra Mohnen; Brian H Davison
Journal:  Biotechnol Biofuels       Date:  2017-12-22       Impact factor: 6.040

5.  Phyto-SERM constitutes from Flemingia macrophylla.

Authors:  Wan-Chun Lai; Ya-Ting Tsui; Abdel Nasser B Singab; Mohamed El-Shazly; Ying-Chi Du; Tsong-Long Hwang; Chin-Chung Wu; Ming-Hong Yen; Ching-Kuo Lee; Ming-Feng Hou; Yang-Chang Wu; Fang-Rong Chang
Journal:  Int J Mol Sci       Date:  2013-07-26       Impact factor: 5.923
  5 in total

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