OBJECTIVE: To investigate the expression of galectin-3 (Gal-3) in prolactinomas. METHODS: Expressions of Gal-3 were evaluated by immunohistochemistry using polyclonal antibody in 16 invasive prolactinomas and 16 prolactinomas. RESULTS: Gal-3 was expressed both in invasive prolactinomas and noninvasive prolactinomas while significantly higher expression seen in the invasive prolactinomas (P < 0.05). CONCLUSION: Gal-3 expression may be used as a useful indicator to determine the invasiveness and prognosis of prolactinomas.
OBJECTIVE: To investigate the expression of galectin-3 (Gal-3) in prolactinomas. METHODS: Expressions of Gal-3 were evaluated by immunohistochemistry using polyclonal antibody in 16 invasive prolactinomas and 16 prolactinomas. RESULTS:Gal-3 was expressed both in invasive prolactinomas and noninvasive prolactinomas while significantly higher expression seen in the invasive prolactinomas (P < 0.05). CONCLUSION:Gal-3 expression may be used as a useful indicator to determine the invasiveness and prognosis of prolactinomas.