Literature DB >> 16038103

A Toll for lupus.

H J Anders1.   

Abstract

Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE). This review summarizes the available data for a role of TLR9 signalling in lupus and discusses the following questions that arise from these observations: 1) Is CpG-DNA/TLR9 interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?

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Year:  2005        PMID： 16038103     DOI： 10.1191/0961203305lu2102rr

Source DB:  PubMed          Journal:  Lupus        ISSN： 0961-2033            Impact factor:   2.911


  14 in total

Review 1.  Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention.

Authors:  Christopher G Horton; A Darise Farris
Journal:  Curr Allergy Asthma Rep       Date:  2012-02       Impact factor: 4.806

Review 2.  Targeting Toll-like receptors for treatment of SLE.

Authors:  Christopher G Horton; Zi-jian Pan; A Darise Farris
Journal:  Mediators Inflamm       Date:  2010-09-19       Impact factor: 4.711

3.  Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis.

Authors:  Anna-Marie Fairhurst; Chun Xie; Yuyang Fu; Andrew Wang; Christopher Boudreaux; Xin J Zhou; Ricardo Cibotti; Anthony Coyle; John E Connolly; Edward K Wakeland; Chandra Mohan
Journal:  J Immunol       Date:  2009-10-28       Impact factor: 5.422

4.  Yaa autoimmune phenotypes are conferred by overexpression of TLR7.

Authors:  Anna-Marie Fairhurst; Sun-hee Hwang; Andrew Wang; Xiang-Hong Tian; Christopher Boudreaux; Xin J Zhou; Jose Casco; Quan-Zhen Li; John E Connolly; Edward K Wakeland
Journal:  Eur J Immunol       Date:  2008-07       Impact factor: 5.532

5.  Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese.

Authors:  Chang-Juan Xu; Wen-Hui Zhang; Hai-Feng Pan; Xiang-Pei Li; Jian-Hua Xu; Dong-Qing Ye
Journal:  Mol Biol Rep       Date:  2009-01-07       Impact factor: 2.316

6.  Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.

Authors:  Anna-Marie Fairhurst; Alexis Mathian; John E Connolly; Andrew Wang; Hillery F Gray; Tiffany A George; Christopher D Boudreaux; Xin J Zhou; Quan-Zhen Li; Sophie Koutouzov; Jacques Banchereau; Edward K Wakeland
Journal:  Eur J Immunol       Date:  2008-07       Impact factor: 5.532

Review 7.  [CCL2/MCP1: a novel target in systemic lupus erythematosus and lupus nephritis].

Authors:  O Kulkarni; H-J Anders
Journal:  Z Rheumatol       Date:  2008-05       Impact factor: 1.372

Review 8.  The pathogenesis of systemic lupus erythematosus-an update.

Authors:  Jinyoung Choi; Sang Taek Kim; Joe Craft
Journal:  Curr Opin Immunol       Date:  2012-11-03       Impact factor: 7.486

9.  Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.

Authors:  Kayoko Tao; Mutsuko Fujii; Shin-ichi Tsukumo; Yoichi Maekawa; Kenji Kishihara; Yasutaka Kimoto; Takahiko Horiuchi; Hajime Hisaeda; Shizuo Akira; Shoji Kagami; Koji Yasutomo
Journal:  Ann Rheum Dis       Date:  2007-03-07       Impact factor: 19.103

10.  Toll-like receptor and accessory molecule mRNA expression in humans and mice as well as in murine autoimmunity, transient inflammation, and progressive fibrosis.

Authors:  Santhosh Kumar Vankyala Ramaiah; Roman Günthner; Maciej Lech; Hans-Joachim Anders
Journal:  Int J Mol Sci       Date:  2013-06-26       Impact factor: 5.923
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