BACKGROUND: We report a genome linkage scan in extended Utah pedigrees, utilizing a pedigree-splitting approach to reduce intra-familial heterogeneity. METHODS: Fifty-nine pedigrees with at least four Prostate cancer (PrCa) cases and no more than two meioses separating PrCa cases were analyzed using the CIDR genomic search STRP marker set. Parametric linkage analyses using dominant and recessive models were performed on four datasets resulting from a pedigree splitting algorithm. In addition, age at diagnosis subset analyses were performed. RESULTS: Four regions of interest (LODs>1.9) were identified on chromosomes 1p, 3q, 5q, and 22q. The linkage peaks on 1p, 3q, and 22q have been previously implicated for PrCa, though not significantly. The 1p region was supported by a single large Utah pedigree with a multipoint LOD score of 3.1. An additional 10 regions gave LOD scores>1.22 (nominal linkage evidence), including moderate evidence supporting the HPC20 region with a recessive model. CONCLUSIONS: Our genome-wide search in the informative, extended Utah pedigrees continues to illustrate an ability to identify and replicate linkage peaks, and supports four regions of interest for PrCa predisposition genes. Copyright (c) 2005 Wiley-Liss, Inc.
BACKGROUND: We report a genome linkage scan in extended Utah pedigrees, utilizing a pedigree-splitting approach to reduce intra-familial heterogeneity. METHODS: Fifty-nine pedigrees with at least four Prostate cancer (PrCa) cases and no more than two meioses separating PrCa cases were analyzed using the CIDR genomic search STRP marker set. Parametric linkage analyses using dominant and recessive models were performed on four datasets resulting from a pedigree splitting algorithm. In addition, age at diagnosis subset analyses were performed. RESULTS: Four regions of interest (LODs>1.9) were identified on chromosomes 1p, 3q, 5q, and 22q. The linkage peaks on 1p, 3q, and 22q have been previously implicated for PrCa, though not significantly. The 1p region was supported by a single large Utah pedigree with a multipoint LOD score of 3.1. An additional 10 regions gave LOD scores>1.22 (nominal linkage evidence), including moderate evidence supporting the HPC20 region with a recessive model. CONCLUSIONS: Our genome-wide search in the informative, extended Utah pedigrees continues to illustrate an ability to identify and replicate linkage peaks, and supports four regions of interest for PrCa predisposition genes. Copyright (c) 2005 Wiley-Liss, Inc.
Authors: Jianfeng Xu; Latchezar Dimitrov; Bao-Li Chang; Tamara S Adams; Aubrey R Turner; Deborah A Meyers; Rosalind A Eeles; Douglas F Easton; William D Foulkes; Jacques Simard; Graham G Giles; John L Hopper; Lovise Mahle; Pal Moller; Tim Bishop; Chris Evans; Steve Edwards; Julia Meitz; Sarah Bullock; Questa Hope; Chih-Lin Hsieh; Jerry Halpern; Raymond N Balise; Ingrid Oakley-Girvan; Alice S Whittemore; Charles M Ewing; Marta Gielzak; Sarah D Isaacs; Patrick C Walsh; Kathleen E Wiley; William B Isaacs; Stephen N Thibodeau; Shannon K McDonnell; Julie M Cunningham; Katherine E Zarfas; Scott Hebbring; Daniel J Schaid; Danielle M Friedrichsen; Kerry Deutsch; Suzanne Kolb; Michael Badzioch; Gail P Jarvik; Marta Janer; Leroy Hood; Elaine A Ostrander; Janet L Stanford; Ethan M Lange; Jennifer L Beebe-Dimmer; Caroline E Mohai; Kathleen A Cooney; Tarja Ikonen; Agnes Baffoe-Bonnie; Henna Fredriksson; Mika P Matikainen; Teuvo Lj Tammela; Joan Bailey-Wilson; Johanna Schleutker; Christiane Maier; Kathleen Herkommer; Josef J Hoegel; Walther Vogel; Thomas Paiss; Fredrik Wiklund; Monica Emanuelsson; Elisabeth Stenman; Bjorn-Anders Jonsson; Henrik Gronberg; Nicola J Camp; James Farnham; Lisa A Cannon-Albright; Daniela Seminara Journal: Am J Hum Genet Date: 2005-06-29 Impact factor: 11.025
Authors: Bo Johanneson; Shannon K McDonnell; Danielle M Karyadi; Pascale Quignon; Laura McIntosh; Shaun M Riska; Liesel M FitzGerald; Gregory Johnson; Kerry Deutsch; Gabrielle Williams; Lori S Tillmans; Janet L Stanford; Daniel J Schaid; Stephen N Thibodeau; Elaine A Ostrander Journal: Hum Mol Genet Date: 2010-07-14 Impact factor: 6.150
Authors: Daniel J Schaid; Janet L Stanford; Shannon K McDonnell; Miia Suuriniemi; Laura McIntosh; Danielle M Karyadi; Erin E Carlson; Kerry Deutsch; Marta Janer; Lee Hood; Elaine A Ostrander Journal: Hum Genet Date: 2007-05-08 Impact factor: 4.132
Authors: Bo Johanneson; Shannon K McDonnell; Danielle M Karyadi; Scott J Hebbring; Liang Wang; Kerry Deutsch; Laura McIntosh; Erika M Kwon; Miia Suuriniemi; Janet L Stanford; Daniel J Schaid; Elaine A Ostrander; Stephen N Thibodeau Journal: Hum Genet Date: 2007-12-08 Impact factor: 4.132
Authors: Nicola J Camp; Lisa A Cannon-Albright; James M Farnham; Agnes B Baffoe-Bonnie; Asha George; Isaac Powell; Joan E Bailey-Wilson; John D Carpten; Graham G Giles; John L Hopper; Gianluca Severi; Dallas R English; William D Foulkes; Lovise Maehle; Pal Moller; Ros Eeles; Douglas Easton; Michael D Badzioch; Alice S Whittemore; Ingrid Oakley-Girvan; Chih-Lin Hsieh; Latchezar Dimitrov; Jianfeng Xu; Janet L Stanford; Bo Johanneson; Kerry Deutsch; Laura McIntosh; Elaine A Ostrander; Kathleen E Wiley; Sarah D Isaacs; Patrick C Walsh; Stephen N Thibodeau; Shannon K McDonnell; Scott Hebbring; Daniel J Schaid; Ethan M Lange; Kathleen A Cooney; Teuvo L J Tammela; Johanna Schleutker; Thomas Paiss; Christiane Maier; Henrik Grönberg; Fredrik Wiklund; Monica Emanuelsson; William B Isaacs Journal: Hum Mol Genet Date: 2007-05-03 Impact factor: 6.150
Authors: Daniel J Schaid; Shannon K McDonnell; Katherine E Zarfas; Julie M Cunningham; Scott Hebbring; Stephen N Thibodeau; Rosalind A Eeles; Douglas F Easton; William D Foulkes; Jacques Simard; Graham G Giles; John L Hopper; Lovise Mahle; Pal Moller; Michael Badzioch; D Timothy Bishop; Chris Evans; Steve Edwards; Julia Meitz; Sarah Bullock; Questa Hope; Michelle Guy; Chih-lin Hsieh; Jerry Halpern; Raymond R Balise; Ingrid Oakley-Girvan; Alice S Whittemore; Jianfeng Xu; Latchezar Dimitrov; Bao-Li Chang; Tamara S Adams; Aubrey R Turner; Deborah A Meyers; Danielle M Friedrichsen; Kerry Deutsch; Suzanne Kolb; Marta Janer; Leroy Hood; Elaine A Ostrander; Janet L Stanford; Charles M Ewing; Marta Gielzak; Sarah D Isaacs; Patrick C Walsh; Kathleen E Wiley; William B Isaacs; Ethan M Lange; Lindsey A Ho; Jennifer L Beebe-Dimmer; David P Wood; Kathleen A Cooney; Daniela Seminara; Tarja Ikonen; Agnes Baffoe-Bonnie; Henna Fredriksson; Mika P Matikainen; Teuvo L J Tammela; Joan Bailey-Wilson; Johanna Schleutker; Christiane Maier; Kathleen Herkommer; Josef J Hoegel; Walther Vogel; Thomas Paiss; Fredrik Wiklund; Monica Emanuelsson; Elisabeth Stenman; Björn-Anders Jonsson; Henrik Grönberg; Nicola J Camp; James Farnham; Lisa A Cannon-Albright; William J Catalona; Brian K Suarez; Kimberly A Roehl Journal: Hum Genet Date: 2006-08-25 Impact factor: 4.132
Authors: Kristina Allen-Brady; James M Farnham; Nicola J Camp; Eric Karlins; Elaine A Ostrander; Lisa A Cannon-Albright Journal: BMC Res Notes Date: 2009-05-28