Gábor Vogt1, Erzsébet Puhó, Andrew E Czeizel. 1. Hospital and Central Outpatients Clinics of the Hungarian State Railways, Podmaniczky u. 111, H-1062 Budapest, Hungary. gabor.vogt@tosho.hu
Abstract
AIMS: To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit. RESULTS: Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% CI: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases. CONCLUSIONS: It is necessary to study the preventable environmental factors in the origin of these ocular defects.
AIMS: To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit. RESULTS: Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% CI: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases. CONCLUSIONS: It is necessary to study the preventable environmental factors in the origin of these ocular defects.
Authors: Evan B Selzer; Delphine Blain; Robert B Hufnagel; Philip J Lupo; Laura E Mitchell; Brian P Brooks Journal: Surv Ophthalmol Date: 2021-12-31 Impact factor: 6.197
Authors: Malena Daich Varela; Robert B Hufnagel; Bin Guan; Delphine Blain; Julie C Sapp; Andrea L Gropman; Ramakrishna Alur; Jennifer J Johnston; Leslie G Biesecker; Brian P Brooks Journal: Ophthalmic Genet Date: 2021-03-15 Impact factor: 1.274