OBJECTIVES: To assess antidepressant response in late-onset major depression in relation to neuropsychological domains: attention, memory and planning. METHODS: A neuropsychological battery was administered in 30 medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen within a 12-month follow-up period. Logistic regression was used to define a predictive model of recovery. RESULTS: Eighteen patients were classed as remitters and seven as non-remitters. The 'indexrem' refers to the results of a logistic regression from verbal learning and planning and had a global predictive power of 84%. CONCLUSIONS: Our study suggests that the balance between verbal learning (memory) and planning (executive function)-both related to the dorsolateral prefrontal cortex-could predicts recovery. (c) 2005 John Wiley & Sons, Ltd.
OBJECTIVES: To assess antidepressant response in late-onset major depression in relation to neuropsychological domains: attention, memory and planning. METHODS: A neuropsychological battery was administered in 30 medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen within a 12-month follow-up period. Logistic regression was used to define a predictive model of recovery. RESULTS: Eighteen patients were classed as remitters and seven as non-remitters. The 'indexrem' refers to the results of a logistic regression from verbal learning and planning and had a global predictive power of 84%. CONCLUSIONS: Our study suggests that the balance between verbal learning (memory) and planning (executive function)-both related to the dorsolateral prefrontal cortex-could predicts recovery. (c) 2005 John Wiley & Sons, Ltd.
Authors: Monique A Pimontel; David Rindskopf; Bret R Rutherford; Patrick J Brown; Steven P Roose; Joel R Sneed Journal: Am J Geriatr Psychiatry Date: 2015-05-21 Impact factor: 4.105
Authors: Marianne Gorlyn; John G Keilp; Michael F Grunebaum; Bonnie P Taylor; Maria A Oquendo; Gerard E Bruder; Jonathan W Stewart; Gil Zalsman; J John Mann Journal: J Neural Transm (Vienna) Date: 2008-07-16 Impact factor: 3.575
Authors: Scott A Langenecker; Susan E Kennedy; Leslie M Guidotti; Emily M Briceno; Lawrence S Own; Thomas Hooven; Elizabeth A Young; Huda Akil; Douglas C Noll; Jon-Kar Zubieta Journal: Biol Psychiatry Date: 2007-06-21 Impact factor: 13.382