OBJECTIVE: The liver is thought to be responsible for multiple organ failure during sepsis. Increase in tissue oxygen consumption is a major component of the septic response. Hyperbaric oxygen (HBO) therapy provides more oxygenation in the whole body. This study examined the effect of HBO alone or in combination with cefepime (CEF) on the liver in septic rats. DESIGN AND INTERVENTIONS: We divided 90 male rats into six groups; control, HBO, sepsis (SEP), SEP+HBO, SEP+CEF, and SEP+CEF+HBO. Sepsis was induced with an intraperitoneal injection of Escherichia coli (2.1 x 10(9) cfu). A total of six HBO sessions were performed at 2 atm absolute for 90 min at 6-h intervals. CEF was administered intraperitoneally at a dose of 50 mg/kg twice daily. Animals were killed 48 h after sepsis induction. Their liver and blood were removed for biochemical and histopathological analysis. MEASUREMENTS AND RESULTS: Liver thiobarbituric acid reactive substances as well as serum alanine transaminase, aspartate transaminase and alkaline phosphatase levels increased while the activity of the antioxidant enzymes superoxide dismutase and catalase decreased significantly in septic rats. These parameters returned to nearly control levels in the SEP+CEF+HBO group. Histological observations supported these findings: Hepatocellular degeneration was observed and intensive polymorphonuclear cell infiltration appeared in all fields of septic animal livers. HBO alone could not sufficiently reverse these histopathological changes, but most liver sections presented normal histology when it was combined with CEF. CONCLUSIONS: HBO may be a useful adjuvant therapy modality to improve the efficacy of sepsis treatment.
OBJECTIVE: The liver is thought to be responsible for multiple organ failure during sepsis. Increase in tissue oxygen consumption is a major component of the septic response. Hyperbaric oxygen (HBO) therapy provides more oxygenation in the whole body. This study examined the effect of HBO alone or in combination with cefepime (CEF) on the liver in septic rats. DESIGN AND INTERVENTIONS: We divided 90 male rats into six groups; control, HBO, sepsis (SEP), SEP+HBO, SEP+CEF, and SEP+CEF+HBO. Sepsis was induced with an intraperitoneal injection of Escherichia coli (2.1 x 10(9) cfu). A total of six HBO sessions were performed at 2 atm absolute for 90 min at 6-h intervals. CEF was administered intraperitoneally at a dose of 50 mg/kg twice daily. Animals were killed 48 h after sepsis induction. Their liver and blood were removed for biochemical and histopathological analysis. MEASUREMENTS AND RESULTS: Liver thiobarbituric acid reactive substances as well as serum alanine transaminase, aspartate transaminase and alkaline phosphatase levels increased while the activity of the antioxidant enzymes superoxide dismutase and catalase decreased significantly in septic rats. These parameters returned to nearly control levels in the SEP+CEF+HBO group. Histological observations supported these findings: Hepatocellular degeneration was observed and intensive polymorphonuclear cell infiltration appeared in all fields of septic animal livers. HBO alone could not sufficiently reverse these histopathological changes, but most liver sections presented normal histology when it was combined with CEF. CONCLUSIONS: HBO may be a useful adjuvant therapy modality to improve the efficacy of sepsis treatment.
Authors: D Gionis; P Kalabalikis; B Zachariadis; M Moustaki; E Ourani; K Papazoglou; J Papadatos Journal: Intensive Care Med Date: 2000-03 Impact factor: 17.440
Authors: Danesh Javeshghani; Danesh Javesghani; Sabah N A Hussain; Jonathan Scheidel; Mark T Quinn; Sheldon A Magder Journal: Shock Date: 2003-05 Impact factor: 3.454
Authors: Francesco Imperatore; Salvatore Cuzzocrea; Carlo Luongo; Giovanni Liguori; Antonella Scafuro; Antonella De Angelis; Francesco Rossi; Achille P Caputi; Amelia Filippelli Journal: Intensive Care Med Date: 2004-02-12 Impact factor: 17.440
Authors: Semra Demirbilek; Mehmet Ozcan Ersoy; Savaş Demirbilek; Abdurrahman Karaman; Melih Akin; Mehmet Bayraktar; Nihayet Bayraktar Journal: Intensive Care Med Date: 2004-03-26 Impact factor: 17.440
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerome Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker Journal: Intensive Care Med Date: 2006-02-18 Impact factor: 17.440
Authors: Serdar Kahraman; Bülent Düz; Hakan Kayali; Ahmet Korkmaz; Sükrü Oter; Ahmet Aydin; Ahmet Sayal Journal: Neurochem Res Date: 2007-05-08 Impact factor: 3.996
Authors: Ana B Parabucki; Iva D Bozić; Ivana M Bjelobaba; Irena C Lavrnja; Predrag D Brkić; Tomislav S Jovanović; Danijela Z Savić; Mirjana B Stojiljković; Sanja M Peković Journal: Croat Med J Date: 2012-12 Impact factor: 1.351
Authors: Levent Yamanel; Umit Kaldirim; Yesim Oztas; Omer Coskun; Yavuz Poyrazoglu; Murat Durusu; Tuncer Cayci; Ahmet Ozturk; Seref Demirbas; Mehmet Yasar; Orhan Cinar; Salim Kemal Tuncer; Yusuf Emrah Eyi; Bulent Uysal; Turgut Topal; Sukru Oter; Ahmet Korkmaz Journal: Int J Med Sci Date: 2011-01-03 Impact factor: 3.738
Authors: Kemal Simsek; Mehmet Ozler; Ali Osman Yildirim; Serdar Sadir; Seref Demirbas; Muzaffer Oztosun; Ahmet Korkmaz; Hakan Ay; Sukru Oter; Senol Yildiz Journal: ScientificWorldJournal Date: 2012-02-02
Authors: Christian R Gomez; Gaylord J Knutson; Kari B Clifton; Claire A Schreiber; Stanimir Vuk-Pavlović Journal: Biogerontology Date: 2012-01-24 Impact factor: 4.277