Literature DB >> 16033284

A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.

Lalji K Gediya1, Pankaj Chopra, Puranik Purushottamachar, Neha Maheshwari, Vincent C O Njar.   

Abstract

We have developed a procedure for the synthesis of N-hydroxy-N(1)-phenyloctanediamide (suberoylanilide hydroxamic acid (SAHA)), providing the product in 79.8% yield. SAHA is a potent inhibitor of histone deacetylase, induces differentiation and/or apoptosis in certain transformed cells in culture, and suppressed the growth of human prostate cancer LNCaP and PC-3 cell lines. The combination of SAHA with other compounds inhibited cell proliferation of LNCaP cells in additive fashion and resulted in synergistic growth inhibition.

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Year:  2005        PMID： 16033284     DOI： 10.1021/jm058214k

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  30 in total

1.  Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.

Authors:  Swati S More; Melissa Itsara; Xiaodong Yang; Ethan G Geier; Michelle K Tadano; Youngho Seo; Henry F Vanbrocklin; William A Weiss; Sabine Mueller; Daphne A Haas-Kogan; Steven G Dubois; Katherine K Matthay; Kathleen M Giacomini
Journal:  Clin Cancer Res       Date:  2011-03-18       Impact factor: 12.531

2.  Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.

Authors:  Min-Yu Chen; Warren S-L Liao; Zhen Lu; William G Bornmann; Violeta Hennessey; Michele N Washington; Gary L Rosner; Yinhua Yu; Ahmed Ashour Ahmed; Robert C Bast
Journal:  Cancer       Date:  2011-10-01       Impact factor: 6.860

3.  The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.

Authors:  Brian M Zeglis; NagaVaraKishore Pillarsetty; Vadim Divilov; Ronald A Blasberg; Jason S Lewis
Journal:  Nucl Med Biol       Date:  2011-03-03       Impact factor: 2.408

Review 4.  An overview of naturally occurring histone deacetylase inhibitors.

Authors:  Bumki Kim; Jiyong Hong
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

5.  In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

Authors:  J Adam Hendricks; Edmund J Keliher; Brett Marinelli; Thomas Reiner; Ralph Weissleder; Ralph Mazitschek
Journal:  J Med Chem       Date:  2011-07-18       Impact factor: 7.446

6.  H2O2/Peroxynitrite-Activated Hydroxamic Acid HDAC Inhibitor Prodrugs Show Antileukemic Activities against AML Cells.

Authors:  Yi Liao; Liping Xu; Siyu Ou; Holly Edwards; Daniel Luedtke; Yubin Ge; Zhihui Qin
Journal:  ACS Med Chem Lett       Date:  2018-06-13       Impact factor: 4.345

7.  Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.

Authors:  Mark Kilgore; Courtney A Miller; Daniel M Fass; Krista M Hennig; Stephen J Haggarty; J David Sweatt; Gavin Rumbaugh
Journal:  Neuropsychopharmacology       Date:  2009-12-09       Impact factor: 7.853

8.  Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model.

Authors:  Yongseok Choi; Song-Kyu Park; Hwan Mook Kim; Jong Soon Kang; Yeo Dae Yoon; Sang Bae Han; Jeung Whan Han; Jee Sun Yang; Gyoonhee Han
Journal:  Exp Mol Med       Date:  2008-10-31       Impact factor: 8.718

9.  Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.

Authors:  Lalji K Gediya; Aashvini Belosay; Aakanksha Khandelwal; Puranik Purushottamachar; Vincent C O Njar
Journal:  Bioorg Med Chem       Date:  2007-12-08       Impact factor: 3.641

10.  Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment.

Authors:  Trisha S Tavares; David Nanus; Ximing J Yang; Lorraine J Gudas
Journal:  Cancer Biol Ther       Date:  2008-10-09       Impact factor: 4.742
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