Literature DB >> 16033283

5'-Homoneplanocin A inhibits hepatitis B and hepatitis C.

Minmin Yang1, Stewart W Schneller, Brent Korba.   

Abstract

As an outgrowth of our program to develop an efficient synthesis of 5'-homoneplanocin A, its antiviral potential was explored beyond that already in the literature. From that, this compound was found to have meaningful activity toward hepatitis B and hepatitis C, which represents an example of one agent effective toward both viruses. These data and an improved preparation of 5'-homoneplanocin A are reported.

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Year:  2005        PMID: 16033283     DOI: 10.1021/jm058200e

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  3 in total

1.  Synthesis of the 6'-iso analogues of neplanocin A and 5'-homoneplanocin A.

Authors:  Wei Ye; Mingzhu He; Stewart W Schneller
Journal:  Tetrahedron Lett       Date:  2009-12-23       Impact factor: 2.415

2.  Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action.

Authors:  Masaaki Toyama; Koichi Watashi; Masanori Ikeda; Atsuya Yamashita; Mika Okamoto; Kohji Moriishi; Masamichi Muramatsu; Takaji Wakita; Ashoke Sharon; Masanori Baba
Journal:  Antimicrob Agents Chemother       Date:  2022-05-23       Impact factor: 5.938

3.  Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).

Authors:  Balakumar Arumugham; Hyo-Joong Kim; Mark N Prichard; Earl R Kern; Chung K Chu
Journal:  Bioorg Med Chem Lett       Date:  2005-11-03       Impact factor: 2.940

  3 in total

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