Literature DB >> 16033252

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Anders A Jensen1, Bente Frølund, Tommy Liljefors, Povl Krogsgaard-Larsen.   

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Year:  2005        PMID： 16033252     DOI： 10.1021/jm040219e

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  156 in total

1.  Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.

Authors:  Li-Fang Yu; Werner Tückmantel; J Brek Eaton; Barbara Caldarone; Allison Fedolak; Taleen Hanania; Dani Brunner; Ronald J Lukas; Alan P Kozikowski
Journal:  J Med Chem       Date:  2012-01-04       Impact factor: 7.446

2.  Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.

Authors:  Brandon J Henderson; Ryan E Pavlovicz; Jerad D Allen; Tatiana F González-Cestari; Crina M Orac; Andrew B Bonnell; Michael X Zhu; R Thomas Boyd; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  J Pharmacol Exp Ther       Date:  2010-06-15       Impact factor: 4.030

3.  Virtual screening against acetylcholine binding protein.

Authors:  Maleeruk Utsintong; Piyanuch Rojsanga; Kwok-Yiu Ho; Todd T Talley; Arthur J Olson; Kinzo Matsumoto; Opa Vajragupta
Journal:  J Biomol Screen       Date:  2011-09-28

4.  Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses.

Authors:  Akos Nemecz; Palmer Taylor
Journal:  J Biol Chem       Date:  2011-10-18       Impact factor: 5.157

5.  Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor.

Authors:  Ayman K Hamouda; Ze-Jun Wang; Deirdre S Stewart; Atul D Jain; Richard A Glennon; Jonathan B Cohen
Journal:  Mol Pharmacol       Date:  2015-04-13       Impact factor: 4.436

6.  3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors.

Authors:  Brandon J Henderson; Crina M Orac; Iwona Maciagiewicz; Stephen C Bergmeier; Dennis B McKay
Journal:  Bioorg Med Chem Lett       Date:  2011-11-20       Impact factor: 2.823

7.  A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.

Authors:  Qiang Liu; Yao Huang; Fenqin Xue; Alain Simard; Jamie DeChon; Guohui Li; Jianliang Zhang; Linda Lucero; Min Wang; Michael Sierks; Gang Hu; Yongchang Chang; Ronald J Lukas; Jie Wu
Journal:  J Neurosci       Date:  2009-01-28       Impact factor: 6.167

8.  Identifying the lipid-protein interface of the alpha4beta2 neuronal nicotinic acetylcholine receptor: hydrophobic photolabeling studies with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine.

Authors:  Ayman K Hamouda; Mitesh Sanghvi; David C Chiara; Jonathan B Cohen; Michael P Blanton
Journal:  Biochemistry       Date:  2007-11-10       Impact factor: 3.162

9.  Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.

Authors:  Derk J Hogenkamp; Thomas A Ford-Hutchinson; Wen-Yen Li; Edward R Whittemore; Ryan F Yoshimura; Minhtam B Tran; Timothy B C Johnstone; Gavin D Bascom; Hannah Rollins; Lena Lu; Kelvin W Gee
Journal:  J Med Chem       Date:  2013-10-30       Impact factor: 7.446

10.  Auto/paracrine control of inflammatory cytokines by acetylcholine in macrophage-like U937 cells through nicotinic receptors.

Authors:  Alexander I Chernyavsky; Juan Arredondo; Maryna Skok; Sergei A Grando
Journal:  Int Immunopharmacol       Date:  2009-12-18       Impact factor: 4.932
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