PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p < 0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.
PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p < 0.05). CONCLUSION:Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.
Authors: Priscila Portugal Dos Santos; Bruna Paola Murino Rafacho; Andréa de Freitas Gonçalves; Rodrigo Gibin Jaldin; Thiago Bruder do Nascimento; Marcondes Alves Barbosa Silva; Stêfany Bruno Assis Cau; Meliza Goi Roscani; Paula Schimdt Azevedo; Marcos Ferreira Minicucci; Rita de Cássia Tostes; Leonardo Antonio Memede Zornoff; Sergio Alberto Rupp de Paiva Journal: PLoS One Date: 2014-06-12 Impact factor: 3.240
Authors: Marcela Polachini Prata; Rodrigo Gibin Jaldin; Pedro Luiz Toledo de Arruda Lourenção; Marcone Lima Sobreira; Ricardo de Alvarenga Yoshida; Simone Antunes Terra; Rosa Marlene Viero; Winston Bonetti Yoshida Journal: J Vasc Bras Date: 2020-03-12