Literature DB >> 16032324

Microphthalmia in Texel lambs.

W D Roe1, D M West, M T Walshe, R D Jolly.   

Abstract

AIM: To describe an outbreak of congenital microphthalmia in Texel lambs in New Zealand.
METHODS: Affected eyes were fixed in 10% formol saline, processed routinely for histopathology and stained with haematoxylin and eosin, Holme's silver and haematoxylin with and without luxol fast blue, and luxol fast blue alone.
RESULTS: Macroscopically, the globes and optic nerves were hypoplastic. Histologically, all embryonic components of the eye were present, but the lens, ciliary body, iris and retina were dysplastic. Axons of the hypoplastic optic nerve were poorly myelinated.
CONCLUSIONS: Congenital microphthalmia occurs in Texel sheep in New Zealand, and is likely inherited as an autosomal recessive trait.

Entities:  

Year:  2003        PMID: 16032324     DOI: 10.1080/00480169.2003.36364

Source DB:  PubMed          Journal:  N Z Vet J        ISSN: 0048-0169            Impact factor:   1.628


  1 in total

1.  Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene.

Authors:  Doreen Becker; Jens Tetens; Adrian Brunner; Daniela Bürstel; Martin Ganter; James Kijas; Cord Drögemüller
Journal:  PLoS One       Date:  2010-01-13       Impact factor: 3.240

  1 in total

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