Literature DB >> 16030443

Mortality and morbidity from moderate to severe traumatic brain injury in Argentina.

Carlos Rondina1, Walter Videtta, Gustavo Petroni, Silvia Lujan, Pablo Schoon, Lilian Benito Mori, Javier Matkovich, Nancy Carney, Randall Chesnut.   

Abstract

UNLABELLED: After adopting the Guidelines for the Management of Severe Head Injury, critical care physicians in Argentina reduced the mortality rate of patients with traumatic brain injury (TBI). However, there is no in-hospital or postdischarge rehabilitation services for persons with TBI in Argentina. Thus, severely disabled survivors were being discharged to home without follow-up or long-term care.
OBJECTIVES: The objectives of this project were to establish a structure for conducting research about TBI in Argentina, and to conduct a prospective, observational study of outcomes from TBI in hospitals that had adopted the acute care guidelines. The goal was to document outcomes for people treated in a medical system that does not provide TBI rehabilitation. The focus of this report is mortality and morbidity during the acute care and hospital ward treatment of TBI in Argentina.
METHODS: We established a data-collection system in 5 hospitals in Argentina, using instruments and protocols developed by the NIDRR-funded TBI Model System program. Data-collection intervals were established to be comparable with intervals used in the TBI Model System program. The Argentine team consists of 11 neurocritical care physicians and 1 project manager/translator. All patient evaluation, data collection and entry, quality control, and local administration were conducted by this group.
RESULTS: Over 31 months, 278 patients were entered into the study. Approximately 61% were discharged from acute care directly to home. The in-hospital mortality rate was 31%. Seventy-six percent of expired patients died from secondary complications such as sepsis and pneumonia, and 93% while in the hospital. DISCUSSION: TBI is a major public health concern in Argentina. However, rehabilitation for TBI is not a part of this country's medical system. The greatest proportion of expired patients in the Argentine sample died of secondary complications such as pneumonia or sepsis, which may have been avoided employing basic medical rehabilitation. The next research questions to be addressed in this population should be designed to identify solutions to the immediate need for rehabilitation, including treatment efficacy questions as well as questions about systems for delivering treatments.

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Year:  2005        PMID: 16030443     DOI: 10.1097/00001199-200507000-00008

Source DB:  PubMed          Journal:  J Head Trauma Rehabil        ISSN: 0885-9701            Impact factor:   2.710


  12 in total

1.  Postdischarge Care of Pediatric Traumatic Brain Injury in Argentina: A Multicenter Randomized Controlled Trial.

Authors:  Nancy A Carney; Gustavo J Petroni; Silvia B Luján; Nicolás M Ballarini; Gabriela A Faguaga; Hugo E M du Coudray; Amy E Huddleston; Gloria M Baggio; Juan M Becerra; Leonardo O Busso; Sureyya S Dikmen; Roberto Falcone; Mirta E García; Osvaldo R González Carrillo; Paula L Medici; Marta B Quaglino; Carina A Randisi; Silvia S Sáenz; Nancy R Temkin; Elida E Vanella
Journal:  Pediatr Crit Care Med       Date:  2016-07       Impact factor: 3.624

2.  Aberrant ER Stress Induced Neuronal-IFNβ Elicits White Matter Injury Due to Microglial Activation and T-Cell Infiltration after TBI.

Authors:  Tanusree Sen; Pampa Saha; Rajaneesh Gupta; Lesley M Foley; Tong Jiang; Olena S Abakumova; T Kevin Hitchens; Nilkantha Sen
Journal:  J Neurosci       Date:  2019-11-06       Impact factor: 6.167

3.  Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury.

Authors:  Tanusree Sen; Rajaneesh Gupta; Helen Kaiser; Nilkantha Sen
Journal:  J Neurosci       Date:  2017-05-18       Impact factor: 6.167

Review 4.  An insight into the vision impairment following traumatic brain injury.

Authors:  Nilkantha Sen
Journal:  Neurochem Int       Date:  2017-02-02       Impact factor: 3.921

5.  Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury.

Authors:  Tanusree Sen; Nilkantha Sen
Journal:  Neuropharmacology       Date:  2016-03-09       Impact factor: 5.250

6.  Hypothermia does not increase the risk of infection: a case control study.

Authors:  Marlijn Kamps; Laurens A Bisschops; Johannes G van der Hoeven; Cornelia W E Hoedemaekers
Journal:  Crit Care       Date:  2011-02-03       Impact factor: 9.097

7.  Estrogen Alleviates Sex-Dependent Differences in Lung Bacterial Clearance and Mortality Secondary to Bacterial Pneumonia after Traumatic Brain Injury.

Authors:  Jean-Francois Pittet; Parker J Hu; Jaideep Honavar; Angela P Brandon; Cilina A Evans; Rebekah Muthalaly; Qiang Ding; Brant M Wagener
Journal:  J Neurotrauma       Date:  2020-12-29       Impact factor: 5.269

Review 8.  Multimodality monitoring consensus statement: monitoring in emerging economies.

Authors:  Anthony Figaji; Corina Puppo
Journal:  Neurocrit Care       Date:  2014-12       Impact factor: 3.210

9.  Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury.

Authors:  Jean-Christophe Copin; Marie My Lien Rebetez; Natacha Turck; Xavier Robin; Jean-Charles Sanchez; Karl Schaller; Yvan Gasche; Bernhard Walder
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2012-12-18       Impact factor: 2.953

Review 10.  Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus.

Authors:  Jon Hazeldine; Janet M Lord; Antonio Belli
Journal:  Front Neurol       Date:  2015-11-05       Impact factor: 4.003

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