| Literature DB >> 16029917 |
Jinbo Fang1, Guiyun Wang, Qiong Yang, Jinna Song, Ye Wang, Li Wang.
Abstract
The tumor specific antigen epitope melanoma antigen A1(161--169) (MAGE-A1(161--169)) was displayed on the major protein (p VIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1(161--169) in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1(161--169) specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy.Entities:
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Year: 2005 PMID： 16029917 DOI： 10.1016/j.vaccine.2005.05.024
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641