Literature DB >> 16029151

Structure-function relationships in serine protease-bovine pancreatic trypsin inhibitor interaction.

D Krowarsch1, M Zakrzewska, A O Smalas, J Otlewski.   

Abstract

We report our progress in understanding the structure-function relationships for the interaction between BPTI and serine proteases. We focused on extensive mutagenesis of four crucial positions from the protease binding loop of BPTI. Selected variants were characterized by determination of association constants, stability parameters and structures of protease-inhibitor complexes.

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Year:  2005        PMID： 16029151     DOI： 10.2174/0929866054395275

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  7 in total

1.  Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin.

Authors:  Jakob Leppkes; Nicole Dimos; Bernhard Loll; Thomas Hohmann; Michael Dyrks; Ariane Wieseke; Bettina G Keller; Beate Koksch
Journal:  RSC Chem Biol       Date:  2022-05-19

2.  The trypsin inhibitor panulirin regulates the prophenoloxidase-activating system in the spiny lobster Panulirus argus.

Authors:  Rolando Perdomo-Morales; Vivian Montero-Alejo; Gerardo Corzo; Vladimir Besada; Yamile Vega-Hurtado; Yamile González-González; Erick Perera; Marlene Porto-Verdecia
Journal:  J Biol Chem       Date:  2013-09-18       Impact factor: 5.157

Review 3.  Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

Authors:  Peter Goettig; Viktor Magdolen; Hans Brandstetter
Journal:  Biochimie       Date:  2010-07-06       Impact factor: 4.079

Review 4.  Structural and functional diversities in lepidopteran serine proteases.

Authors:  Ajay Srinivasan; Ashok P Giri; Vidya S Gupta
Journal:  Cell Mol Biol Lett       Date:  2006       Impact factor: 5.787

5.  A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk.

Authors:  Silvia González; Martín Fló; Mariana Margenat; Rosario Durán; Gualberto González-Sapienza; Martín Graña; John Parkinson; Rick M Maizels; Gustavo Salinas; Beatriz Alvarez; Cecilia Fernández
Journal:  PLoS One       Date:  2009-09-17       Impact factor: 3.240

Review 6.  Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders.

Authors:  Rami A Al-Horani; Umesh R Desai
Journal:  Med Res Rev       Date:  2014-03-21       Impact factor: 12.944

7.  A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine.

Authors:  Aleksandra Kvetkina; Elena Leychenko; Victoria Chausova; Elena Zelepuga; Nadezhda Chernysheva; Konstantin Guzev; Evgeny Pislyagin; Ekaterina Yurchenko; Ekaterina Menchinskaya; Dmitry Aminin; Leonid Kaluzhskiy; Alexis Ivanov; Steve Peigneur; Jan Tytgat; Emma Kozlovskaya; Marina Isaeva
Journal:  Sci Rep       Date:  2020-03-06       Impact factor: 4.379
  7 in total

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