Literature DB >> 16029117

Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1.

Herbert Chen1, Muthusamy Kunnimalaiyaan, Jamie J Van Gompel.   

Abstract

Medullary thyroid cancer (MTC) is a prototypic neuroendocrine tumor of the thyroid C cells. Other than surgery, there are no curative therapies for MTC. In this review, we detail recent studies that suggest that targeting specific signaling pathways may be a viable strategy to control MTC tumor progression. Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation.

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Year:  2005        PMID： 16029117     DOI： 10.1089/thy.2005.15.511

Source DB:  PubMed          Journal:  Thyroid        ISSN： 1050-7256            Impact factor:   6.568


  21 in total

1.  Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer.

Authors:  Matthew Truong; Mackenzie R Cook; Scott N Pinchot; Muthusamy Kunnimalaiyaan; Herbert Chen
Journal:  Ann Surg Oncol       Date:  2010-12-24       Impact factor: 5.344

Review 2.  Signaling mechanisms in neuroendocrine tumors as targets for therapy.

Authors:  Barbara Zarebczan; Herbert Chen
Journal:  Endocrinol Metab Clin North Am       Date:  2010-12       Impact factor: 4.741

3.  A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.

Authors:  Diogo S Castro; Ben Martynoga; Carlos Parras; Vidya Ramesh; Emilie Pacary; Caroline Johnston; Daniela Drechsel; Mélanie Lebel-Potter; Laura Galinanes Garcia; Charles Hunt; Dirk Dolle; Angela Bithell; Laurence Ettwiller; Noel Buckley; François Guillemot
Journal:  Genes Dev       Date:  2011-05-01       Impact factor: 11.361

4.  Notch in the development of thyroid C-cells and the treatment of medullary thyroid cancer.

Authors:  Mackenzie Cook; Xiao-Min Yu; Herbert Chen
Journal:  Am J Transl Res       Date:  2010-02-10       Impact factor: 4.060

5.  MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition.

Authors:  Jocelyn F Burke; Logan Schlosser; April D Harrison; Muthusamy Kunnimalaiyaan; Herbert Chen
Journal:  Ann Surg Oncol       Date:  2013-07-31       Impact factor: 5.344

6.  Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer.

Authors:  Mackenzie R Cook; Jie Luo; Mary Ndiaye; Herbert Chen; Muthusamy Kunnimalaiyaan
Journal:  Am J Surg       Date:  2010-03       Impact factor: 2.565

7.  Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro.

Authors:  Yash Somnay; Herbert Chen; Muthusamy Kunnimalaiyaan
Journal:  Neuroendocrinology       Date:  2012-09-04       Impact factor: 4.914

8.  Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways.

Authors:  Muthusamy Kunnimalaiyaan; Mary Ndiaye; Herbert Chen
Journal:  Surgery       Date:  2007-12       Impact factor: 3.982

9.  Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells.

Authors:  David Yu Greenblatt; Max A Cayo; Joel T Adler; Li Ning; Megan R Haymart; Muthusamy Kunnimalaiyaan; Herbert Chen
Journal:  Ann Surg       Date:  2008-06       Impact factor: 12.969

10.  Medullary thyroid carcinoma: targeted therapies and future directions.

Authors:  Scott N Pinchot; Muthusamy Kunnimalaiyaan; Rebecca S Sippel; Herbert Chen
Journal:  J Oncol       Date:  2009-12-24       Impact factor: 4.375
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