Literature DB >> 16028692

Nonviral gene delivery methods in cardiovascular diseases.

Marika Ruponen1, Zanna Hyvönen, Arto Urtti, Seppo Ylä-Herttuala.   

Abstract

Nonviral gene delivery methods with naked plasmids and various plasmid carrier complexes have been used for intravascular, intramuscular and periadventitial gene delivery to cardiovascular system. Efficacy, homogenity and quality of the nonviral gene delivery complexes can be significantly affected by the way they are produced. This chapter presents basic methods to produce nonviral gene delivery complexes and describes common models to test their properties in cardiovascular applications in vivo.

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Year:  2005        PMID： 16028692     DOI： 10.1385/1-59259-850-1:315

Source DB:  PubMed          Journal:  Methods Mol Med        ISSN： 1543-1894


  3 in total

Review 1.  Targeted gene therapy for the treatment of heart failure.

Authors:  Kleopatra Rapti; Antoine H Chaanine; Roger J Hajjar
Journal:  Can J Cardiol       Date:  2011 May-Jun       Impact factor: 5.223

2.  Local gene transfer and expression following intramuscular administration of FGF-1 plasmid DNA in patients with critical limb ischemia.

Authors:  Iris Baumgartner; Nicolas Chronos; Anthony Comerota; Timothy Henry; Jean-Paul Pasquet; François Finiels; Anne Caron; Jean-François Dedieu; Richard Pilsudski; Pia Delaère
Journal:  Mol Ther       Date:  2009-02-24       Impact factor: 11.454

Review 3.  From bench to bedside: review of gene and cell-based therapies and the slow advancement into phase 3 clinical trials, with a focus on Aastrom's Ixmyelocel-T.

Authors:  Ronnda L Bartel; Erin Booth; Caryn Cramer; Kelly Ledford; Sharon Watling; Frank Zeigler
Journal:  Stem Cell Rev Rep       Date:  2013-06       Impact factor: 5.739
  3 in total

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