Literature DB >> 16027880

Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription.

V S Simonova1, A V Samusenko, N A Filippova, A N Tevyashova, L S Lyniv, G I Kulik, V F Chekhun, A A Shtil.   

Abstract

Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription.

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Year:  2005        PMID： 16027880     DOI： 10.1007/s10517-005-0321-3

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression.

Authors:  Zhong Wang; Philip S Lecane; Patricia Thiemann; Qing Fan; Cecilia Cortez; Xuan Ma; Danielle Tonev; Dale Miles; Louie Naumovski; Richard A Miller; Darren Magda; Dong-Gyu Cho; Jonathan L Sessler; Brian L Pike; Samantha M Yeligar; Mazen W Karaman; Joseph G Hacia
Journal:  Mol Cancer       Date:  2007-01-19       Impact factor: 27.401

2.  Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction.

Authors:  Artemy D Beniaminov; Galina V Chashchina; Mikhail A Livshits; Olga I Kechko; Vladimir A Mitkevich; Olga K Mamaeva; Anna N Tevyashova; Alexander A Shtil; Anna K Shchyolkina; Dmitry N Kaluzhny
Journal:  Int J Mol Sci       Date:  2020-07-26       Impact factor: 5.923

3.  Differential Impact of Random GC Tetrad Binding and Chromatin Events on Transcriptional Inhibition by Olivomycin A.

Authors:  Alexandra K Isagulieva; Dmitry N Kaluzhny; Artemy D Beniaminov; Nataliya V Soshnikova; Alexander A Shtil
Journal:  Int J Mol Sci       Date:  2022-08-09       Impact factor: 6.208
  3 in total

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