BACKGROUND: Obesity has recently become a concern for physicians treating schizophrenic patients. Obesity is associated with hypertension, dyslipidemia, and diabetes mellitus. In this pilot study, we investigate which anthropometric measurement, body mass index or waist circumference, is a better predictor of cardiovascular risk factors in patients with schizophrenia. METHOD: This cross-sectional study, conducted from January 2001 to January 2002, examined body fat distribution and its relation to cardiovascular risk factors in 62 patients with schizophrenia (DSM-IV) recruited from an outpatient psychiatric clinic. RESULTS: Chi-square analysis revealed that an increased waist circumference was associated with dyslipidemia (p < .01), hypertension (p < .05), and abnormal serum glucose (p < .05), whereas an increased body mass index was only associated with dyslipidemia (p < .05). In logistic regression analysis, after controlling for age, gender, race, ethnicity, smoking, and body mass index, increased waist circumference remained significantly associated with dyslipidemia (odds ratio = 2.08, 95% CI = 1.01 to 1.15, p < .05) and hypertension (odds ratio = 2.05, 95% CI = 1.02 to 1.17, p < .05). CONCLUSIONS: Waist circumference revealed a stronger correlation than body mass index to cardiovascular risk factors in patients with schizophrenia. We propose the measurement of waist circumference as a screening tool for cardiovascular risk factors in this population. Waist circumference measurement can provide an opportunity for primary prevention of coronary heart disease and diabetes mellitus in patients with schizophrenia.
BACKGROUND: Obesity has recently become a concern for physicians treating schizophrenicpatients. Obesity is associated with hypertension, dyslipidemia, and diabetes mellitus. In this pilot study, we investigate which anthropometric measurement, body mass index or waist circumference, is a better predictor of cardiovascular risk factors in patients with schizophrenia. METHOD: This cross-sectional study, conducted from January 2001 to January 2002, examined body fat distribution and its relation to cardiovascular risk factors in 62 patients with schizophrenia (DSM-IV) recruited from an outpatientpsychiatric clinic. RESULTS: Chi-square analysis revealed that an increased waist circumference was associated with dyslipidemia (p < .01), hypertension (p < .05), and abnormal serum glucose (p < .05), whereas an increased body mass index was only associated with dyslipidemia (p < .05). In logistic regression analysis, after controlling for age, gender, race, ethnicity, smoking, and body mass index, increased waist circumference remained significantly associated with dyslipidemia (odds ratio = 2.08, 95% CI = 1.01 to 1.15, p < .05) and hypertension (odds ratio = 2.05, 95% CI = 1.02 to 1.17, p < .05). CONCLUSIONS: Waist circumference revealed a stronger correlation than body mass index to cardiovascular risk factors in patients with schizophrenia. We propose the measurement of waist circumference as a screening tool for cardiovascular risk factors in this population. Waist circumference measurement can provide an opportunity for primary prevention of coronary heart disease and diabetes mellitus in patients with schizophrenia.
Authors: D B Allison; J L Mentore; M Heo; L P Chandler; J C Cappelleri; M C Infante; P J Weiden Journal: Am J Psychiatry Date: 1999-11 Impact factor: 18.112
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Authors: M I Schmidt; R L Watson; B B Duncan; P Metcalf; F L Brancati; A R Sharrett; C E Davis; G Heiss Journal: Metabolism Date: 1996-06 Impact factor: 8.694
Authors: Tanya E Keenan; Airong Yu; Lisa A Cooper; Lawrence J Appel; Eliseo Guallar; Joseph V Gennusa; Faith B Dickerson; Rosa M Crum; Cheryl A Anderson; Leslie M Campbell; Deborah R Young; Gail L Daumit Journal: Schizophr Res Date: 2013-07-31 Impact factor: 4.939
Authors: Marina Salviato Balbão; Jaime Eduardo Cecílio Hallak; Emerson Arcoverde Nunes; Mauricio Homem de Mello; Andresa de Toledo Triffoni-Melo; Flavia Isaura de Santi Ferreira; Cristiano Chaves; Ana Maria Sertori Durão; Adriana Pelegrino Pinho Ramos; José Alexandre de Souza Crippa; Regina Helena Costa Queiroz Journal: Ther Adv Psychopharmacol Date: 2014-02