Literature DB >> 16026845

Pathophysiological basis of drug-induced dyskinesias in Parkinson's disease.

Milind Deogaonkar1, Thyagarajan Subramanian.   

Abstract

Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients. The pathophysiological basis and clinical nature of DID is of major interest for clinicians and neuroscientists. In this review article, we evaluate the theories of pathophysiology and molecular basis of DID, validity of various animal models used in DID related research, and electrophysiological characteristics of various basal ganglia nuclei during DID. We also discuss the relevance of various treatment strategies to the pathophysiological mechanisms.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16026845     DOI： 10.1016/j.brainresrev.2005.05.005

Source DB:  PubMed          Journal:  Brain Res Brain Res Rev


  6 in total

Review 1.  The interhemispheric connections of the striatum: Implications for Parkinson's disease and drug-induced dyskinesias.

Authors:  Christopher A Lieu; Thyagarajan Subramanian
Journal:  Brain Res Bull       Date:  2011-09-24       Impact factor: 4.077

2.  A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.

Authors:  Christopher A Lieu; Allen R Kunselman; Bala V Manyam; Kala Venkiteswaran; Thyagarajan Subramanian
Journal:  Parkinsonism Relat Disord       Date:  2010-05-31       Impact factor: 4.891

3.  The cross-hemispheric nigrostriatal pathway prevents the expression of levodopa-induced dyskinesias.

Authors:  Vishakh Iyer; Kala Venkiteswaran; Sandip Savaliya; Christopher A Lieu; Erin Handly; Timothy P Gilmour; Allen R Kunselman; Thyagarajan Subramanian
Journal:  Neurobiol Dis       Date:  2021-08-27       Impact factor: 5.996

Review 4.  Nicotine and Parkinson's disease: implications for therapy.

Authors:  Maryka Quik; Kathryn O'Leary; Caroline M Tanner
Journal:  Mov Disord       Date:  2008-09-15       Impact factor: 10.338

5.  The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate.

Authors:  Christopher A Lieu; Kala Venkiteswaran; Timothy P Gilmour; Anand N Rao; Andrew C Petticoffer; Erin V Gilbert; Milind Deogaonkar; Bala V Manyam; Thyagarajan Subramanian
Journal:  Evid Based Complement Alternat Med       Date:  2012-09-10       Impact factor: 2.629

Review 6.  An Update on Medical and Surgical Treatments of Parkinson's Disease.

Authors:  Dipali Nemade; Thyagarajan Subramanian; Vikram Shivkumar
Journal:  Aging Dis       Date:  2021-07-01       Impact factor: 6.745
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.