Literature DB >> 16025425

A neuroendocrinological hypothesis on gender effects of naltrexone in relapse prevention treatment.

F Kiefer, H Jahn, K Wiedemann.   

Abstract

The ability of naltrexone to increase hypothalamo-pituitary-adrenocortical (HPA)-axis activity was recently reported to be associated with its effects on the reduction of craving for alcohol. We now present data showing naltrexone to be more efficacious in female alcoholics. Since HPA-axis might be interpreted as a key mechanism of action that could explain the observed gender differences in the abstinence maintenance treatment of alcohol addiction.

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Year:  2005        PMID： 16025425     DOI： 10.1055/s-2005-871244

Source DB:  PubMed          Journal:  Pharmacopsychiatry        ISSN： 0176-3679            Impact factor:   5.788


  7 in total

1.  Gender differences in alcohol treatment: an analysis of outcome from the COMBINE study.

Authors:  Shelly F Greenfield; Helen M Pettinati; Stephanie O'Malley; Patrick K Randall; Carrie L Randall
Journal:  Alcohol Clin Exp Res       Date:  2010-07-20       Impact factor: 3.455

2.  A Systematic Review of Naltrexone for Attenuating Alcohol Consumption in Women with Alcohol Use Disorders.

Authors:  Shantrel S Canidate; Giselle D Carnaby; Christa L Cook; Robert L Cook
Journal:  Alcohol Clin Exp Res       Date:  2017-02-03       Impact factor: 3.455

3.  Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis.

Authors:  Martin O Job; Amanda Tang; F Scott Hall; Ichiro Sora; George R Uhl; Susan E Bergeson; Rueben A Gonzales
Journal:  Biol Psychiatry       Date:  2007-03-06       Impact factor: 13.382

4.  Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence.

Authors:  Helen M Pettinati; Kyle M Kampman; Kevin G Lynch; Jesse J Suh; Charles A Dackis; David W Oslin; Charles P O'Brien
Journal:  J Subst Abuse Treat       Date:  2007-07-30

5.  Naltrexone alters alcohol self-administration behaviors and hypothalamic-pituitary-adrenal axis activity in a sex-dependent manner in rats.

Authors:  Steven J Nieto; Cana B Quave; Therese A Kosten
Journal:  Pharmacol Biochem Behav       Date:  2018-02-24       Impact factor: 3.533

6.  Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.

Authors:  Evan D Morris; Suchitra Krishnan-Sarin; Bart de Laat; Nabeel Nabulsi; Yiyun Huang; Stephanie S O'Malley; Janice C Froehlich
Journal:  Mol Psychiatry       Date:  2020-06-15       Impact factor: 15.992

7.  Naltrexone long-acting formulation in the treatment of alcohol dependence.

Authors:  Bankole A Johnson
Journal:  Ther Clin Risk Manag       Date:  2007-10       Impact factor: 2.423
  7 in total

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