Literature DB >> 16024513

Genomes optimize reproduction: aging as a consequence of the developmental program.

João Pedro de Magalhães1, George M Church.   

Abstract

Natural selection shapes genomes for reproduction, not for postreproductive survival. One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein we review, revive, and refine the developmental theory of aging. Implications and experimental approaches for studying the progressive deterioration of physiological function that we call aging are also discussed.

Mesh：

Year:  2005        PMID： 16024513     DOI： 10.1152/physiol.00010.2005

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  34 in total

1.  Integration of immunity with physical and cognitive function in definitions of successful aging.

Authors:  Patricia Griffin; Joshua J Michel; Kristy Huysman; Alison J Logar; Abbe N Vallejo
Journal:  Aging Dis       Date:  2012-02-27       Impact factor: 6.745

2.  MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.

Authors:  Mehmet Somel; Song Guo; Ning Fu; Zheng Yan; Hai Yang Hu; Ying Xu; Yuan Yuan; Zhibin Ning; Yuhui Hu; Corinna Menzel; Hao Hu; Michael Lachmann; Rong Zeng; Wei Chen; Philipp Khaitovich
Journal:  Genome Res       Date:  2010-07-20       Impact factor: 9.043

Review 3.  Human embryonic stem cells: mechanisms to escape replicative senescence?

Authors:  Xianmin Zeng
Journal:  Stem Cell Rev       Date:  2007-12       Impact factor: 5.739

4.  Meta-analysis of age-related gene expression profiles identifies common signatures of aging.

Authors:  João Pedro de Magalhães; João Curado; George M Church
Journal:  Bioinformatics       Date:  2009-02-02       Impact factor: 6.937

Review 5.  Unraveling genetic origin of aging-related traits: evolving concepts.

Authors:  Alexander M Kulminski
Journal:  Rejuvenation Res       Date:  2013-08       Impact factor: 4.663

Review 6.  A synopsis on aging-Theories, mechanisms and future prospects.

Authors:  João Pinto da Costa; Rui Vitorino; Gustavo M Silva; Christine Vogel; Armando C Duarte; Teresa Rocha-Santos
Journal:  Ageing Res Rev       Date:  2016-06-25       Impact factor: 10.895

Review 7.  Gene expression in the human brain: the current state of the study of specificity and spatiotemporal dynamics.

Authors:  Oksana Yu Naumova; Maria Lee; Sergei Yu Rychkov; Natalia V Vlasova; Elena L Grigorenko
Journal:  Child Dev       Date:  2012-11-12

8.  Testing predictions of the programmed and stochastic theories of aging: comparison of variation in age at death, menopause, and sexual maturation.

Authors:  N S Gavrilova; L A Gavrilov; F F Severin; V P Skulachev
Journal:  Biochemistry (Mosc)       Date:  2012-07       Impact factor: 2.487

9.  The life cycle of the kidney: implications for CKD.

Authors:  Robert L Chevalier
Journal:  J Am Soc Nephrol       Date:  2014-05-08       Impact factor: 10.121

10.  DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells.

Authors:  Simone Bork; Stefan Pfister; Hendrik Witt; Patrick Horn; Bernhard Korn; Anthony D Ho; Wolfgang Wagner
Journal:  Aging Cell       Date:  2009-11-06       Impact factor: 9.304
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