Literature DB >> 1602302

Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.

K Chen1, Q A Shi, T Fujioka, D C Zhang, C Q Hu, J Q Jin, R E Kilkuskie, K H Lee.   

Abstract

A new kaurane-type diterpene lactone, tripterifordin [1], has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques that involved the 1H-1H COSY, heteronucleus-detected variants of the heteronuclear chemical shift correlation (HETCOR), phase-sensitive NOESY, and long-range HETCOR. Compound 1 shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.

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Year:  1992        PMID： 1602302     DOI： 10.1021/np50079a013

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Cobalt-Catalyzed Hydrogen-Atom Transfer Induces Bicyclizations that Tolerate Electron-Rich and Electron-Deficient Intermediate Alkenes.

Authors:  Darius Vrubliauskas; Christopher D Vanderwal
Journal:  Angew Chem Int Ed Engl       Date:  2020-02-25       Impact factor: 15.336

2.  Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii.

Authors:  Lichan Tu; Xinbo Cai; Yifeng Zhang; Yuru Tong; Jian Wang; Ping Su; Yun Lu; Tianyuan Hu; Yunfeng Luo; Xiaoyi Wu; Dan Li; Luqi Huang; Wei Gao
Journal:  Acta Pharm Sin B       Date:  2022-02-22       Impact factor: 14.903

3.  Three-Dimensional Large-Scale Fused Silica Microfluidic Chips Enabled by Hybrid Laser Microfabrication for Continuous-Flow UV Photochemical Synthesis.

Authors:  Aodong Zhang; Jian Xu; Yucen Li; Ming Hu; Zijie Lin; Yunpeng Song; Jia Qi; Wei Chen; Zhaoxiang Liu; Ya Cheng
Journal:  Micromachines (Basel)       Date:  2022-03-30       Impact factor: 3.523

4.  Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function of ent-Kaurene Oxidase Supported by NADPH-Cytochrome P450 Reductases in Tripterygium wilfordii.

Authors:  Ping Su; Hongyu Guan; Yifeng Zhang; Xing Wang; Linhui Gao; Yujun Zhao; Tianyuan Hu; Jiawei Zhou; Baowei Ma; Lichan Tu; Yuru Tong; Luqi Huang; Wei Gao
Journal:  Front Plant Sci       Date:  2017-10-13       Impact factor: 5.753

Review 5.  The potential of plant systems to break the HIV-TB link.

Authors:  Peyman Habibi; Henry Daniell; Carlos Ricardo Soccol; Maria Fatima Grossi-de-Sa
Journal:  Plant Biotechnol J       Date:  2019-07-18       Impact factor: 9.803

Review 6.  Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.

Authors:  Ramandeep Kaur; Pooja Sharma; Girish K Gupta; Fidele Ntie-Kang; Dinesh Kumar
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

Review 7.  Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents.

Authors:  R Sagaya Jansi; Ameer Khusro; Paul Agastian; Ahmed Alfarhan; Naif Abdullah Al-Dhabi; Mariadhas Valan Arasu; Rajakrishnan Rajagopal; Damia Barcelo; Amal Al-Tamimi
Journal:  Sci Total Environ       Date:  2020-11-07       Impact factor: 7.963

8.  Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.

Authors:  Wan-Fei Li; Juan Wang; Jing-Jie Zhang; Xun Song; Chuen-Fai Ku; Juan Zou; Ji-Xin Li; Li-Jun Rong; Lu-Tai Pan; Hong-Jie Zhang
Journal:  Int J Mol Sci       Date:  2015-11-24       Impact factor: 5.923

Review 9.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923
  9 in total

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