| Literature DB >> 16020724 |
Najib M El-Sayed1, Peter J Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A Worthey, Christiane Hertz-Fowler, Elodie Ghedin, Christopher Peacock, Daniella C Bartholomeu, Brian J Haas, Anh-Nhi Tran, Jennifer R Wortman, U Cecilia M Alsmark, Samuel Angiuoli, Atashi Anupama, Jonathan Badger, Frederic Bringaud, Eithon Cadag, Jane M Carlton, Gustavo C Cerqueira, Todd Creasy, Arthur L Delcher, Appolinaire Djikeng, T Martin Embley, Christopher Hauser, Alasdair C Ivens, Sarah K Kummerfeld, Jose B Pereira-Leal, Daniel Nilsson, Jeremy Peterson, Steven L Salzberg, Joshua Shallom, Joana C Silva, Jaideep Sundaram, Scott Westenberger, Owen White, Sara E Melville, John E Donelson, Björn Andersson, Kenneth D Stuart, Neil Hall.
Abstract
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that-along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions-have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.Entities:
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Year: 2005 PMID： 16020724 DOI： 10.1126/science.1112181
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728