| Literature DB >> 16019211 |
Shinnosuke Hosoda1, Aya Tanatani, Ken-ichi Wakabayashi, Yusuke Nakano, Hiroyuki Miyachi, Kazuo Nagasawa, Yuichi Hashimoto.
Abstract
Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.Entities:
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Year: 2005 PMID： 16019211 DOI： 10.1016/j.bmcl.2005.06.044
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823