| Literature DB >> 16019083 |
Tiziana Genovese1, Emanuela Mazzon, Antonietta Rossi, Rosanna Di Paola, Giuseppe Cannavò, Carmelo Muià, Concetta Crisafulli, Placido Bramanti, Lidia Sautebin, Salvatore Cuzzocrea.
Abstract
A traumatic spinal cord injury (SCI) induces a sequelae of events which conduce biochemical and cellular alterations. Here we compare the degree of spinal cord injury caused by the application of vascular clips, in mice lacking the 5-lipoxygenase and in the corresponding wild-type mice. Biochemical, immunohistochemical and functional studies revealed respectively an increase of neutrophils infiltration, of IL-1beta, TNF-alpha immunoreactivity, apoptosis (measured by Annexin-V staining) and loss of hind legs movement in SCI operated 5-LO wild-type mice. In contrast, the degree of (1) neutrophil infiltration at different time points, (2) cytokine expression (TNF-alpha and IL-1beta), (3) histological damage, (4) apoptosis, was markedly reduced in the tissues obtained from SCI operated 5-LO deficient mice and (5) the motor recovery was ameliorated.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16019083 DOI： 10.1016/j.jneuroim.2005.05.009
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478