| Literature DB >> 16018965 |
Abstract
MicroRNAs (miRNAs), 18-25 nt single-stranded RNAs, act as regulators in fine-tuning gene function. The absence of miRNAs is not life-threatening in early embryonic development of Dicer-knockout zebrafish and mice, which may account for genetic expression of various traits as a result of miRNA complexity in higher animals during natural evolution. The Pol-II-mediated intronic miRNA is a useful tool to validate the function of computer-predicated miRNAs in zebrafish and mice.Entities:
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Year: 2005 PMID: 16018965 PMCID: PMC1581492 DOI: 10.1016/j.bbrc.2005.06.130
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN: 0006-291X Impact factor: 3.575