Vaiyapuri Manju1, Namasivayam Nalini. 1. Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608002, Tamilnadu, India.
Abstract
BACKGROUND: Ginger (Zingiber officinale Rosc) is a natural dietary component, which has antioxidant and anticarcinogenic properties. We investigated the effect of ginger on the initiation and post-initiation stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats. METHODS: Rats were given a weekly subcutaneous injection of DMH (20 mg/kg body weight) in the groin for 15 weeks. Ginger (50 mg/kg body weight/everyday p.o.) was given to the rats at the initiation, post-initiation stages of carcinogenesis. The activity of lipid peroxidation was studied by measuring the formation of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH) and conjugated dienes (CD), and the antioxidant status by measuring superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST), glutathione reductase (GR), reduced glutathione (GSH), vitamins C, E, and A concentrations in the circulation of 1,2-dimethylhydrazine-induced experimental colon cancer. RESULTS: In the presence of a known colon carcinogen, DMH, plasma lipid peroxidation (TBARS, lipid hydroperoxides and conjugated dienes) and cancer incidence were significantly increased whereas enzymic (GPx, GST, GR, SOD and CAT) and non-enzymic antioxidant concentrations (GSH, vitamins C, E, and A) were decreased as compared to control rats. The number of tumors as well as the incidence of cancer was significantly decreased on treatment with ginger. In addition, ginger supplementation at the initiation stage and also at the post-initiation stages of carcinogenesis significantly reduced circulating lipid peroxidation and significantly enhanced the enzymic and non-enzymic antioxidants as compared to unsupplemented DMH-treated rats. CONCLUSIONS: Ginger supplementation suppresses colon carcinogenesis in the presence of the procarcinogen DMH.
BACKGROUND:Ginger (Zingiber officinale Rosc) is a natural dietary component, which has antioxidant and anticarcinogenic properties. We investigated the effect of ginger on the initiation and post-initiation stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats. METHODS:Rats were given a weekly subcutaneous injection of DMH (20 mg/kg body weight) in the groin for 15 weeks. Ginger (50 mg/kg body weight/everyday p.o.) was given to the rats at the initiation, post-initiation stages of carcinogenesis. The activity of lipid peroxidation was studied by measuring the formation of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH) and conjugated dienes (CD), and the antioxidant status by measuring superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-S-transferase (GST), glutathione reductase (GR), reduced glutathione (GSH), vitamins C, E, and A concentrations in the circulation of 1,2-dimethylhydrazine-induced experimental colon cancer. RESULTS: In the presence of a known colon carcinogen, DMH, plasma lipid peroxidation (TBARS, lipid hydroperoxides and conjugated dienes) and cancer incidence were significantly increased whereas enzymic (GPx, GST, GR, SOD and CAT) and non-enzymic antioxidant concentrations (GSH, vitamins C, E, and A) were decreased as compared to control rats. The number of tumors as well as the incidence of cancer was significantly decreased on treatment with ginger. In addition, ginger supplementation at the initiation stage and also at the post-initiation stages of carcinogenesis significantly reduced circulating lipid peroxidation and significantly enhanced the enzymic and non-enzymic antioxidants as compared to unsupplemented DMH-treated rats. CONCLUSIONS:Ginger supplementation suppresses colon carcinogenesis in the presence of the procarcinogen DMH.
Authors: Suzanna M Zick; D Kim Turgeon; Jianwei Ren; Mack T Ruffin; Benjamin D Wright; Ananda Sen; Zora Djuric; Dean E Brenner Journal: Mol Carcinog Date: 2014-04-24 Impact factor: 4.784
Authors: Abdul Hamid Hafizah; Zakaria Zaiton; Amom Zulkhairi; Adenan Mohd Ilham; Megat Mohd Nordin Nor Anita; Abdullah Mahdy Zaleha Journal: J Zhejiang Univ Sci B Date: 2010-05 Impact factor: 3.066
Authors: Mun Yhung Jung; Min Kyoung Lee; Hee Jeong Park; Eun-Bi Oh; Je Young Shin; Ji Su Park; Su Young Jung; Jung-Hee Oh; Dong-Seong Choi Journal: Food Sci Biotechnol Date: 2017-12-29 Impact factor: 2.391
Authors: Yan Luo; Aimee L Eggler; Dongting Liu; Guowen Liu; Andrew D Mesecar; Richard B van Breemen Journal: J Am Soc Mass Spectrom Date: 2007-10-02 Impact factor: 3.109
Authors: Yan Jiang; Danielle K Turgeon; Benjamin D Wright; Elkhansa Sidahmed; Mack T Ruffin; Dean E Brenner; Ananda Sen; Suzanna M Zick Journal: Eur J Cancer Prev Date: 2013-09 Impact factor: 2.497