BACKGROUND: Human immunodeficiency virus (HIV) infection frequently results in neurological complications but the impact of different neurological syndromes on patients' quality of life remains unknown. METHODS: We investigated health-related quality of life (HRQoL) parameters among HIV/Acquired Immune Deficiency Syndrome (AIDS) patients with and without neurological disease, including 11 dimensions of HRQoL within the Medical Outcomes Short-form Health Survey-HIV. RESULTS: Comparisons of sociodemographic and systemic clinical variables did not differ between HIV/AIDS patients with (n=94) and without (n=75) neurological disease. However, patients with neurological diseases exhibited significantly lower HRQoL scores compared to matched controls, which was most evident among HIV/AIDS patients with cognitive impairment and sensory neuropathy. Prospective analysis revealed diminishing HRQoL scores prior to neurological diagnosis followed by a progressive and sustained improvement in HRQoL scores after intervention over a 96-week period. CONCLUSIONS: These studies indicate that while HIV-related neurological diseases are associated with reduced HRQoL scores, enhanced neurological care has a positive impact on HIV/AIDS patients' overall well-being.
BACKGROUND: Human immunodeficiency virus (HIV) infection frequently results in neurological complications but the impact of different neurological syndromes on patients' quality of life remains unknown. METHODS: We investigated health-related quality of life (HRQoL) parameters among HIV/Acquired Immune Deficiency Syndrome (AIDS) patients with and without neurological disease, including 11 dimensions of HRQoL within the Medical Outcomes Short-form Health Survey-HIV. RESULTS: Comparisons of sociodemographic and systemic clinical variables did not differ between HIV/AIDSpatients with (n=94) and without (n=75) neurological disease. However, patients with neurological diseases exhibited significantly lower HRQoL scores compared to matched controls, which was most evident among HIV/AIDSpatients with cognitive impairment and sensory neuropathy. Prospective analysis revealed diminishing HRQoL scores prior to neurological diagnosis followed by a progressive and sustained improvement in HRQoL scores after intervention over a 96-week period. CONCLUSIONS: These studies indicate that while HIV-related neurological diseases are associated with reduced HRQoL scores, enhanced neurological care has a positive impact on HIV/AIDSpatients' overall well-being.
Authors: Jennifer A McCombe; Farshid Noorbakhsh; Craig Buchholz; Michael Trew; Christopher Power Journal: J Psychiatry Neurosci Date: 2009-03 Impact factor: 6.186
Authors: Beau K Nakamoto; Aaron McMurtray; James Davis; Victor Valcour; Michael R Watters; Bruce Shiramizu; Dominic C Chow; Kalpana Kallianpur; Cecilia M Shikuma Journal: AIDS Res Hum Retroviruses Date: 2010-07 Impact factor: 2.205
Authors: Christopher Power; Elizabeth Hui; Pornpun Vivithanaporn; Shaona Acharjee; Maria Polyak Journal: J Neuroimmune Pharmacol Date: 2011-09-15 Impact factor: 4.147
Authors: Taylor Harrison; Sachiko Miyahara; Anthony Lee; Scott Evans; Barbara Bastow; David Simpson; Ian Gilron; Robert Dworkin; Eric S Daar; Linda Wieclaw; David B Clifford Journal: Pain Med Date: 2013-04-08 Impact factor: 3.750