Literature DB >> 1601668

Production of 6-[18F]fluoro-L-dopa and its metabolism in vivo--a critical review.

A Luxen1, M Guillaume, W P Melega, V W Pike, O Solin, R Wagner.   

Abstract

This report critically appraises methods for the synthesis of 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-FDOPA) that are based on labelling by non-regioselective electrophilic fluorination, regioselective fluorodemetalation or nucleophilic substitution. Recommendations for the standardization of labelling procedures, the optimization of radiochemical yield and the assurance of product quality and safety are given. Studies of the metabolism of 6-FDOPA in vivo are also reviewed to emphasize the importance of the biochemical component of the development of this tracer for positron emission tomography (PET).

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Year:  1992        PMID： 1601668     DOI： 10.1016/0883-2897(92)90002-g

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum B        ISSN： 0883-2897


  15 in total

Review 1.  Tracers for metabolic imaging of brain and heart. Radiochemistry and radiopharmacology.

Authors:  G Stöcklin
Journal:  Eur J Nucl Med       Date:  1992

2.  Comparative diagnostic accuracy of contrast-enhanced MRI and (18)F-FDOPA PET-CT in recurrent glioma.

Authors:  Sellam Karunanithi; Punit Sharma; Abhishek Kumar; Bangkim Chandra Khangembam; Guru Pada Bandopadhyaya; Rakesh Kumar; Ajit Goenka; Deepak Kumar Gupta; Arun Malhotra; Chandrasekhar Bal
Journal:  Eur Radiol       Date:  2013-04-28       Impact factor: 5.315

Review 3.  Radiosyntheses using fluorine-18: the art and science of late stage fluorination.

Authors:  Erin L Cole; Megan N Stewart; Ryan Littich; Raphael Hoareau; Peter J H Scott
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

4.  Experience of 6-l-[18F]FDOPA Production Using Commercial Disposable Cassettes and an Automated Module.

Authors:  Raviteja Nanabala; Maroor Raghavan Ambikalmajan Pillai; Buvaneswari Gopal
Journal:  Nucl Med Mol Imaging       Date:  2022-04-06

5.  Arene radiofluorination enabled by photoredox-mediated halide interconversion.

Authors:  Wei Chen; Hui Wang; Nicholas E S Tay; Vincent A Pistritto; Kang-Po Li; Tao Zhang; Zhanhong Wu; David A Nicewicz; Zibo Li
Journal:  Nat Chem       Date:  2021-12-13       Impact factor: 24.274

Review 6.  Clinical application of 18F-DOPA PET/TC in pediatric patients.

Authors:  Gabriele Masselli; Emanuele Casciani; Cristina De Angelis; Saadi Sollaku; Gianfranco Gualdi
Journal:  Am J Nucl Med Mol Imaging       Date:  2021-04-15

7.  Positron emission tomography (PET) imaging with (18)F-based radiotracers.

Authors:  Mian M Alauddin
Journal:  Am J Nucl Med Mol Imaging       Date:  2011-12-15

8.  Characteristics of 18F-FDG and 18F-FDOPA PET in an 8-year-old neutered male Yorkshire Terrier dog with glioma: long-term chemotherapy using hydroxyurea plus imatinib with prednisolone and immunoreactivity for PDGFR-β and LAT1.

Authors:  Taesik Yun; Yoonhoi Koo; Sanggu Kim; Wonguk Lee; Hakhyun Kim; Dongwoo Chang; Soochong Kim; Mhan-Pyo Yang; Byeong-Teck Kang
Journal:  Vet Q       Date:  2021-12       Impact factor: 3.320

Review 9.  Normal biodistribution pattern and physiologic variants of 18F-DOPA PET imaging.

Authors:  Sotirios Chondrogiannis; Maria Cristina Marzola; Adil Al-Nahhas; Thirumalesha D Venkatanarayana; Alberto Mazza; Giuseppe Opocher; Domenico Rubello
Journal:  Nucl Med Commun       Date:  2013-12       Impact factor: 1.690

Review 10.  6-[18F]fluoro-L-DOPA: a well-established neurotracer with expanding application spectrum and strongly improved radiosyntheses.

Authors:  M Pretze; C Wängler; B Wängler
Journal:  Biomed Res Int       Date:  2014-05-28       Impact factor: 3.411
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