| Literature DB >> 1601130 |
P Gillery1, C Fertin, J F Nicolas, F Chastang, B Kalis, J Banchereau, F X Maquart.
Abstract
A role for the cytokines produced by tissue-infiltrated inflammatory cells (mainly T-lymphocytes and mast cells) in the pathophysiology of fibrosis has been suggested by several groups. Among the products of these cells, interleukin-4 (IL-4) might be one of the factors involved in the initiation of the fibrotic process. We studied the effects of recombinant human IL-4 on human fibroblast monolayer cultures. IL-4 (10 and 100 U/ml) induced a dose-dependent increase of collagen production. Non-collagen protein synthesis was not significantly altered. A concomitant increase of pro-alpha 1(I) collagen mRNAs was observed, showing that IL-4 acts at a pre-translational level.Entities:
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Year: 1992 PMID： 1601130 DOI： 10.1016/0014-5793(92)80448-p
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124