Literature DB >> 1601070

Felbamate reduces hypoxic-ischemic brain damage in vivo.

C G Wasterlain1, L M Adams, H Hattori, P H Schwartz.   

Abstract

The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.

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Year:  1992        PMID： 1601070     DOI： 10.1016/0014-2999(92)90343-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Cognitive Adverse Effects of Antiepileptic Drugs : Incidence, Mechanisms and Therapeutic Implications.

Authors:  R Kälviäinen; M Äikiä; P J Riekkinen
Journal:  CNS Drugs       Date:  1996-05       Impact factor: 5.749

Review 2.  Limiting neurological damage after stroke: a review of pharmacological treatment options.

Authors:  S J Read; T Hirano; S M Davis; G A Donnan
Journal:  Drugs Aging       Date:  1999-01       Impact factor: 3.923

3.  Electrophysiological actions of felbamate on rat striatal neurones.

Authors:  A Pisani; A Stefani; A Siniscalchi; N B Mercuri; G Bernardi; P Calabresi
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

Review 4.  Felbamate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in epilepsy.

Authors:  Katharine J Palmer; Donna McTavish
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546

Review 5.  Clinical management of seizures in newborns : diagnosis and treatment.

Authors:  Linda G M van Rooij; Marcel P H van den Broek; Carin M A Rademaker; Linda S de Vries
Journal:  Paediatr Drugs       Date:  2013-02       Impact factor: 3.022

6.  Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.

Authors:  Beatrix S Traa; Justin D Mulholland; Shilpa D Kadam; Michael V Johnston; Anne M Comi
Journal:  Pediatr Res       Date:  2008-07       Impact factor: 3.756

7.  Felbamate as an oral add-on therapy in six dogs with presumptive idiopathic epilepsy and generalized seizures resistant to drug therapy.

Authors:  Curtis Wells Dewey; Mark Rishniw; Kasie Sakovitch
Journal:  Open Vet J       Date:  2022-07-11
  7 in total

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