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Literature DB >> 1601047

High frequency of cord blood lymphocytes against mycobacterial 65-kDa heat-shock protein.

Abstract

A high frequency of nonadherent mononuclear cells in human cord blood proliferates in response to mycobacterial 65-kDa heat-shock protein. The frequency range in cord blood is not different from that in peripheral blood of Bacillus Calmette-Guérin vaccinated adults. In comparison we found 10 to 100 times lower frequencies to purified protein derivative in nonadherent cord blood mononuclear cells than in adult peripheral blood mononuclear cells. These findings may provide experimental support for Cohen's theory of the immunological homonculus.

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Year: 1992 PMID： 1601047 DOI： 10.1002/eji.1830220651

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

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Cited

9 in total

1. Cytokine analysis at the single cell level and lymphoproliferative responses to mycobacterial antigens in HIV-1 patients with successful virologic response to potent antiretrovirals.

Authors: C Amiel; J P Kusnierz; Y Mouton; G Rook; J Stanford; M Singh; A Capron; G M Bahr
Journal: J Clin Immunol Date: 2000-11 Impact factor: 8.317

2. Human cord blood T-cell receptor alpha beta cell responses to protein antigens of Paracoccidioides brasiliensis yeast forms.

Authors: M E Munk; S H Kaufmann
Journal: Immunology Date: 1995-01 Impact factor: 7.397

3. In vitro human lymphocyte proliferative responses to a glycoprotein of the yeast Saccharomyces cerevisiae.

Authors: C J Darroch; S E Christmas; R M Barnes
Journal: Immunology Date: 1994-02 Impact factor: 7.397

Review 4. Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.

Authors: E Zonneveld-Huijssoon; S Albani; B J Prakken; F van Wijk
Journal: Clin Exp Immunol Date: 2013-01 Impact factor: 4.330

5. Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro.

Authors: Adriana Motta; Carla Schmitz; Luiz Rodrigues; Flávia Ribeiro; Cesar Teixeira; Thiago Detanico; Carla Bonan; Heather Zwickey; Cristina Bonorino
Journal: Immunology Date: 2007-03-07 Impact factor: 7.397

High frequency of cord blood lymphocytes against mycobacterial 65-kDa heat-shock protein.

1. Cytokine analysis at the single cell level and lymphoproliferative responses to mycobacterial antigens in HIV-1 patients with successful virologic response to potent antiretrovirals.

2. Human cord blood T-cell receptor alpha beta cell responses to protein antigens of Paracoccidioides brasiliensis yeast forms.

3. In vitro human lymphocyte proliferative responses to a glycoprotein of the yeast Saccharomyces cerevisiae.

Review 4. Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.

5. Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro.

6. HSP60: issues and insights on its therapeutic use as an immunoregulatory agent.

7. The anti-inflammatory mechanisms of Hsp70.

8. Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors.

9. Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals.