Literature DB >> 16009537

Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.

R Wielgo-Polanin1, L Lagarce, E Gautron, B Diquet, P Lainé-Cessac.   

Abstract

Here we report on a case of hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Alternative causes of liver injury were excluded. The pathophysiological mechanism remains unclear, with a possibility of allergic reaction. In view of the widespread use of both drugs, clinicians should be aware of this drug-induced liver injury.

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Year:  2005        PMID: 16009537     DOI: 10.1016/j.ijantimicag.2005.04.019

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN: 0924-8579            Impact factor:   5.283


  7 in total

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Authors:  Stephen J Balevic; Shruti M Raja; Rachel Randell; Gregory A Deye; Thomas Conrad; Aya Nakamura; David H Peyton; Sandra Shotwell; Katherine Liebman; Michael Cohen-Wolkowiez; Jeffrey T Guptill
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Review 7.  New concepts in antimalarial use and mode of action in dermatology.

Authors:  Sunil Kalia; Jan P Dutz
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  7 in total

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