| Literature DB >> 16009505 |
Abstract
The effects of embelin (50 mg/kg/day), a benzoquinone derivative of Embelia ribes, and the effects of curcumin (100 mg/kg/day), the active principle of Curcuma longa, against N-nitrosodiethylamine (DENA)-initiated and phenobarbital (PB)-promoted hepatocarcinogenesis were studied in Wistar rats. They were able to prevent the induction of hepatic hyper plastic nodules, body weight loss, increase in the levels of hepatic diagnostic markers, and hypoproteinemia induced by DENA/PB treatment. Hence, results of our study suggest the possible chemopreventive effects of embelin (EMB) and curcumin (CUR) against DENA/PB-induced hepatocarcinogenesis in Wistar rats.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16009505 DOI： 10.1016/j.fitote.2005.04.014
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882